Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains

T cells from strains responder to the antigen poly(Glu40 Ala60) (GA) were depleted of alloreactive cells by bromo-deoxyuridine and light treatment, and were subsequently primed in vitro in GA presented by allogeneic macrophages from nonresponder strains. Antigen-specific secondary proliferative resp...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1981
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186446/
https://www.ncbi.nlm.nih.gov/pubmed/6792318
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collection PubMed
description T cells from strains responder to the antigen poly(Glu40 Ala60) (GA) were depleted of alloreactive cells by bromo-deoxyuridine and light treatment, and were subsequently primed in vitro in GA presented by allogeneic macrophages from nonresponder strains. Antigen-specific secondary proliferative responses restricted by allogeneic Ia molecules of the macrophages were obtained in all strain combinations tested. These data indicate that Ir gene-controlled nonresponsiveness cannot be the result of a failure of antigen presentation.
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spelling pubmed-21864462008-04-17 Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains J Exp Med Articles T cells from strains responder to the antigen poly(Glu40 Ala60) (GA) were depleted of alloreactive cells by bromo-deoxyuridine and light treatment, and were subsequently primed in vitro in GA presented by allogeneic macrophages from nonresponder strains. Antigen-specific secondary proliferative responses restricted by allogeneic Ia molecules of the macrophages were obtained in all strain combinations tested. These data indicate that Ir gene-controlled nonresponsiveness cannot be the result of a failure of antigen presentation. The Rockefeller University Press 1981-09-01 /pmc/articles/PMC2186446/ /pubmed/6792318 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains
title Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains
title_full Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains
title_fullStr Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains
title_full_unstemmed Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains
title_short Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains
title_sort responder t cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186446/
https://www.ncbi.nlm.nih.gov/pubmed/6792318

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