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Antigen recognition. V. Requirement for histocompatibility between antigen-presenting cell and B cell in the response to a thymus- dependent antigen, and lack of allogeneic restriction between T and B cells
The restrictions imposed by the major histocompatibility complex on T-B- antigen-presenting cell (APC) interactions were studied with an in vivo adoptive transfer system, using mutually tolerant T and B cells taken from one-way fetal liver chimeras. It was found that the B cells and adoptive recipie...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1981
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186466/ https://www.ncbi.nlm.nih.gov/pubmed/7276826 |
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collection | PubMed |
description | The restrictions imposed by the major histocompatibility complex on T-B- antigen-presenting cell (APC) interactions were studied with an in vivo adoptive transfer system, using mutually tolerant T and B cells taken from one-way fetal liver chimeras. It was found that the B cells and adoptive recipient (which provides APC function) have to share determinants encoded by the left-hand end of the H-2 complex for cooperation, whereas there is apparently no such requirement for T-B cell syngeneicity. Suppression arising from allogeneic effects between the host and the transferred T or B cells was excluded by the use of tolerant as well as normal adoptive recipients; both were functionally equivalent. We conclude that under experimental conditions, unrestricted helper T cell function and concurrent APC-B cell genetic restriction can be demonstrated in vivo. |
format | Text |
id | pubmed-2186466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1981 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21864662008-04-17 Antigen recognition. V. Requirement for histocompatibility between antigen-presenting cell and B cell in the response to a thymus- dependent antigen, and lack of allogeneic restriction between T and B cells J Exp Med Articles The restrictions imposed by the major histocompatibility complex on T-B- antigen-presenting cell (APC) interactions were studied with an in vivo adoptive transfer system, using mutually tolerant T and B cells taken from one-way fetal liver chimeras. It was found that the B cells and adoptive recipient (which provides APC function) have to share determinants encoded by the left-hand end of the H-2 complex for cooperation, whereas there is apparently no such requirement for T-B cell syngeneicity. Suppression arising from allogeneic effects between the host and the transferred T or B cells was excluded by the use of tolerant as well as normal adoptive recipients; both were functionally equivalent. We conclude that under experimental conditions, unrestricted helper T cell function and concurrent APC-B cell genetic restriction can be demonstrated in vivo. The Rockefeller University Press 1981-09-01 /pmc/articles/PMC2186466/ /pubmed/7276826 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Antigen recognition. V. Requirement for histocompatibility between antigen-presenting cell and B cell in the response to a thymus- dependent antigen, and lack of allogeneic restriction between T and B cells |
title | Antigen recognition. V. Requirement for histocompatibility between antigen-presenting cell and B cell in the response to a thymus- dependent antigen, and lack of allogeneic restriction between T and B cells |
title_full | Antigen recognition. V. Requirement for histocompatibility between antigen-presenting cell and B cell in the response to a thymus- dependent antigen, and lack of allogeneic restriction between T and B cells |
title_fullStr | Antigen recognition. V. Requirement for histocompatibility between antigen-presenting cell and B cell in the response to a thymus- dependent antigen, and lack of allogeneic restriction between T and B cells |
title_full_unstemmed | Antigen recognition. V. Requirement for histocompatibility between antigen-presenting cell and B cell in the response to a thymus- dependent antigen, and lack of allogeneic restriction between T and B cells |
title_short | Antigen recognition. V. Requirement for histocompatibility between antigen-presenting cell and B cell in the response to a thymus- dependent antigen, and lack of allogeneic restriction between T and B cells |
title_sort | antigen recognition. v. requirement for histocompatibility between antigen-presenting cell and b cell in the response to a thymus- dependent antigen, and lack of allogeneic restriction between t and b cells |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186466/ https://www.ncbi.nlm.nih.gov/pubmed/7276826 |