A monoclonal antibody that defines an idiotope with two subsites in galactan-binding myeloma proteins

An IgG1 monoclonal antibody HyX24-14 was derived from A/J mice that were immunized with the IgA XRPC24 (X24) galactan binding myeloma protein (GalBMP) of BALB/c origin by the Kohler-Milstein hybridoma technology. HyX24-14 specifically binds some but all GalBMP. Different patterns of binding using a...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1981
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186553/
https://www.ncbi.nlm.nih.gov/pubmed/7320687
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collection PubMed
description An IgG1 monoclonal antibody HyX24-14 was derived from A/J mice that were immunized with the IgA XRPC24 (X24) galactan binding myeloma protein (GalBMP) of BALB/c origin by the Kohler-Milstein hybridoma technology. HyX24-14 specifically binds some but all GalBMP. Different patterns of binding using a panel of nine Gal BMP were found, depending upon the concentration of antibody and the antigenic target. From molecular models and amino acid sequence data, ti was proposed that the idiotope defined by HyX24-14 had two subsites, each of which appeared to be able to bind independently to the antibody.
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spelling pubmed-21865532008-04-17 A monoclonal antibody that defines an idiotope with two subsites in galactan-binding myeloma proteins J Exp Med Articles An IgG1 monoclonal antibody HyX24-14 was derived from A/J mice that were immunized with the IgA XRPC24 (X24) galactan binding myeloma protein (GalBMP) of BALB/c origin by the Kohler-Milstein hybridoma technology. HyX24-14 specifically binds some but all GalBMP. Different patterns of binding using a panel of nine Gal BMP were found, depending upon the concentration of antibody and the antigenic target. From molecular models and amino acid sequence data, ti was proposed that the idiotope defined by HyX24-14 had two subsites, each of which appeared to be able to bind independently to the antibody. The Rockefeller University Press 1981-12-01 /pmc/articles/PMC2186553/ /pubmed/7320687 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
A monoclonal antibody that defines an idiotope with two subsites in galactan-binding myeloma proteins
title A monoclonal antibody that defines an idiotope with two subsites in galactan-binding myeloma proteins
title_full A monoclonal antibody that defines an idiotope with two subsites in galactan-binding myeloma proteins
title_fullStr A monoclonal antibody that defines an idiotope with two subsites in galactan-binding myeloma proteins
title_full_unstemmed A monoclonal antibody that defines an idiotope with two subsites in galactan-binding myeloma proteins
title_short A monoclonal antibody that defines an idiotope with two subsites in galactan-binding myeloma proteins
title_sort monoclonal antibody that defines an idiotope with two subsites in galactan-binding myeloma proteins
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186553/
https://www.ncbi.nlm.nih.gov/pubmed/7320687

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