During lymphatic regeneration, precursors for major histocompatibility complex-restricted cytotoxic T cells appear before alloreactive precursors

Mice were injected with a sublethal dose of cyclophosphamide (Cy) (300 mg/kg), and the appearance of the capacity of the regenerating spleen to form cytotoxic T lymphocytes (CTL) in response against 2,4,6 trinitrophenyl-coupled syngeneic cells or against allogeneic cells was followed. It was found t...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1982
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186559/
https://www.ncbi.nlm.nih.gov/pubmed/6976415
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collection PubMed
description Mice were injected with a sublethal dose of cyclophosphamide (Cy) (300 mg/kg), and the appearance of the capacity of the regenerating spleen to form cytotoxic T lymphocytes (CTL) in response against 2,4,6 trinitrophenyl-coupled syngeneic cells or against allogeneic cells was followed. It was found that 8 da after Cy injection, the spleen contained cells that could give rise to CTL, but only 2,4,6 trinitrophenyl-specific CTL responses could be obtained at this stage. A low alloresponse was first seen 2 wk after Cy injection.
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spelling pubmed-21865592008-04-17 During lymphatic regeneration, precursors for major histocompatibility complex-restricted cytotoxic T cells appear before alloreactive precursors J Exp Med Articles Mice were injected with a sublethal dose of cyclophosphamide (Cy) (300 mg/kg), and the appearance of the capacity of the regenerating spleen to form cytotoxic T lymphocytes (CTL) in response against 2,4,6 trinitrophenyl-coupled syngeneic cells or against allogeneic cells was followed. It was found that 8 da after Cy injection, the spleen contained cells that could give rise to CTL, but only 2,4,6 trinitrophenyl-specific CTL responses could be obtained at this stage. A low alloresponse was first seen 2 wk after Cy injection. The Rockefeller University Press 1982-01-01 /pmc/articles/PMC2186559/ /pubmed/6976415 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
During lymphatic regeneration, precursors for major histocompatibility complex-restricted cytotoxic T cells appear before alloreactive precursors
title During lymphatic regeneration, precursors for major histocompatibility complex-restricted cytotoxic T cells appear before alloreactive precursors
title_full During lymphatic regeneration, precursors for major histocompatibility complex-restricted cytotoxic T cells appear before alloreactive precursors
title_fullStr During lymphatic regeneration, precursors for major histocompatibility complex-restricted cytotoxic T cells appear before alloreactive precursors
title_full_unstemmed During lymphatic regeneration, precursors for major histocompatibility complex-restricted cytotoxic T cells appear before alloreactive precursors
title_short During lymphatic regeneration, precursors for major histocompatibility complex-restricted cytotoxic T cells appear before alloreactive precursors
title_sort during lymphatic regeneration, precursors for major histocompatibility complex-restricted cytotoxic t cells appear before alloreactive precursors
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186559/
https://www.ncbi.nlm.nih.gov/pubmed/6976415

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