Postnatal expansion of the natural killer and keller cell population in humans identified by the monoclonal HNK-1 antibody

Human natural killer (NK) and killer (K) cells were directly enumerated using a monoclonal antibody (HNK-1) and an immunofluorescence assay. The frequency of cells bearing surface HNK-1 antigen was very low in the newborn (less than 1.0%) and increased progressively through childhood and into adult...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1982
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186573/
https://www.ncbi.nlm.nih.gov/pubmed/7054358
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collection PubMed
description Human natural killer (NK) and killer (K) cells were directly enumerated using a monoclonal antibody (HNK-1) and an immunofluorescence assay. The frequency of cells bearing surface HNK-1 antigen was very low in the newborn (less than 1.0%) and increased progressively through childhood and into adult life. This was correlated with an age-related increase in functional NK and K cell activities. Males had a slightly higher proportion of HNK-1+ cells than females. In addition to HNK-1 expression on the surface membrane, a prominent cytoplasmic expression of HNK-1 antigen was found in some but not all surface HNK-1+ cells. The cytoplasmic accumulation of HNK-1 molecules appeared to occur in more mature cells of this lineage.
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spelling pubmed-21865732008-04-17 Postnatal expansion of the natural killer and keller cell population in humans identified by the monoclonal HNK-1 antibody J Exp Med Articles Human natural killer (NK) and killer (K) cells were directly enumerated using a monoclonal antibody (HNK-1) and an immunofluorescence assay. The frequency of cells bearing surface HNK-1 antigen was very low in the newborn (less than 1.0%) and increased progressively through childhood and into adult life. This was correlated with an age-related increase in functional NK and K cell activities. Males had a slightly higher proportion of HNK-1+ cells than females. In addition to HNK-1 expression on the surface membrane, a prominent cytoplasmic expression of HNK-1 antigen was found in some but not all surface HNK-1+ cells. The cytoplasmic accumulation of HNK-1 molecules appeared to occur in more mature cells of this lineage. The Rockefeller University Press 1982-01-01 /pmc/articles/PMC2186573/ /pubmed/7054358 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Postnatal expansion of the natural killer and keller cell population in humans identified by the monoclonal HNK-1 antibody
title Postnatal expansion of the natural killer and keller cell population in humans identified by the monoclonal HNK-1 antibody
title_full Postnatal expansion of the natural killer and keller cell population in humans identified by the monoclonal HNK-1 antibody
title_fullStr Postnatal expansion of the natural killer and keller cell population in humans identified by the monoclonal HNK-1 antibody
title_full_unstemmed Postnatal expansion of the natural killer and keller cell population in humans identified by the monoclonal HNK-1 antibody
title_short Postnatal expansion of the natural killer and keller cell population in humans identified by the monoclonal HNK-1 antibody
title_sort postnatal expansion of the natural killer and keller cell population in humans identified by the monoclonal hnk-1 antibody
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186573/
https://www.ncbi.nlm.nih.gov/pubmed/7054358

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