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Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells

The immunogenicity of long-surviving, enhanced (AS X AUG)F1 renal allografts retransplanted into secondary AS recipients was restored by the injection of small numbers of donor strain dendritic cells derived from afferent lymph. Whereas 1 X 10(4) to 5 X 10(4) dendritic cells were able to trigger an...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1982
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186574/
https://www.ncbi.nlm.nih.gov/pubmed/7033437
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description The immunogenicity of long-surviving, enhanced (AS X AUG)F1 renal allografts retransplanted into secondary AS recipients was restored by the injection of small numbers of donor strain dendritic cells derived from afferent lymph. Whereas 1 X 10(4) to 5 X 10(4) dendritic cells were able to trigger an acute rejection response, neither the passenger volume of donor strain blood nor 5 X 10(6) T or B lymphocytes were able to do so, thereby demonstrating more than a 100-fold difference in immunogenic potency. It is concluded that intrarenal dendritic cells provide the major immunogenic stimulus of a kidney allograft. These results suggest that the antigenic strength of major histocompatibility complex-incompatible tissue correlates with the content of donor strain dendritic cells. They also provide further evidence that antigens of the major histocompatibility complex behave like conventional antigens unless they are on the surface of allogeneic dendritic cells.
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spelling pubmed-21865742008-04-17 Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells J Exp Med Articles The immunogenicity of long-surviving, enhanced (AS X AUG)F1 renal allografts retransplanted into secondary AS recipients was restored by the injection of small numbers of donor strain dendritic cells derived from afferent lymph. Whereas 1 X 10(4) to 5 X 10(4) dendritic cells were able to trigger an acute rejection response, neither the passenger volume of donor strain blood nor 5 X 10(6) T or B lymphocytes were able to do so, thereby demonstrating more than a 100-fold difference in immunogenic potency. It is concluded that intrarenal dendritic cells provide the major immunogenic stimulus of a kidney allograft. These results suggest that the antigenic strength of major histocompatibility complex-incompatible tissue correlates with the content of donor strain dendritic cells. They also provide further evidence that antigens of the major histocompatibility complex behave like conventional antigens unless they are on the surface of allogeneic dendritic cells. The Rockefeller University Press 1982-01-01 /pmc/articles/PMC2186574/ /pubmed/7033437 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells
title Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells
title_full Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells
title_fullStr Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells
title_full_unstemmed Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells
title_short Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells
title_sort restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186574/
https://www.ncbi.nlm.nih.gov/pubmed/7033437