Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia

An infrequent (2-3%) B lymphocyte subpopulation was found in the normal human tonsil and lymph nodes that shows the phenotypic characteristics of B-chronic lymphocytic leukemia (B-CLL) (rosette formation with mouse erythrocytes, weak expression of membrane Ig, staining for HLA-DR, and OKT1 or Leu-1...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1982
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186600/
https://www.ncbi.nlm.nih.gov/pubmed/6977012
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collection PubMed
description An infrequent (2-3%) B lymphocyte subpopulation was found in the normal human tonsil and lymph nodes that shows the phenotypic characteristics of B-chronic lymphocytic leukemia (B-CLL) (rosette formation with mouse erythrocytes, weak expression of membrane Ig, staining for HLA-DR, and OKT1 or Leu-1 detecting a T cell-associated p65 antigen). Preliminary evidence suggests that at least a subpopulation of these cells is found, in small proportions, within the germinal centers. These cells were not observed in the human bone marrow. B-CLL may involve this peripheral B lymphocyte subset.
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spelling pubmed-21866002008-04-17 Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia J Exp Med Articles An infrequent (2-3%) B lymphocyte subpopulation was found in the normal human tonsil and lymph nodes that shows the phenotypic characteristics of B-chronic lymphocytic leukemia (B-CLL) (rosette formation with mouse erythrocytes, weak expression of membrane Ig, staining for HLA-DR, and OKT1 or Leu-1 detecting a T cell-associated p65 antigen). Preliminary evidence suggests that at least a subpopulation of these cells is found, in small proportions, within the germinal centers. These cells were not observed in the human bone marrow. B-CLL may involve this peripheral B lymphocyte subset. The Rockefeller University Press 1982-02-01 /pmc/articles/PMC2186600/ /pubmed/6977012 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia
title Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia
title_full Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia
title_fullStr Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia
title_full_unstemmed Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia
title_short Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia
title_sort infrequent normal b lymphocytes express features of b-chronic lymphocytic leukemia
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186600/
https://www.ncbi.nlm.nih.gov/pubmed/6977012

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