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Prostaglandin E inhibits the production of human interleukin 2
Prostaglandins of the E type specifically inhibited the production of interleukin 2 (IL-2) by normal human lymphocytes, whereas PG synthetase inhibitors such as indomethacin and fentiazac raised IL-2 production above normal levels. Removal of adherent cells from mononuclear cell populations also res...
| Formato: | Texto |
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| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1982
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186623/ https://www.ncbi.nlm.nih.gov/pubmed/6977613 |
| _version_ | 1782145984898269184 |
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| collection | PubMed |
| description | Prostaglandins of the E type specifically inhibited the production of interleukin 2 (IL-2) by normal human lymphocytes, whereas PG synthetase inhibitors such as indomethacin and fentiazac raised IL-2 production above normal levels. Removal of adherent cells from mononuclear cell populations also resulted in enhanced IL-2 production. The resultant nonadherent cell population lost sensitivity to the enhancement effect of PG synthetase inhibitors, suggesting that a PGE-producing adherent cell plays a major role in the regulation of IL-2. |
| format | Text |
| id | pubmed-2186623 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1982 |
| publisher | The Rockefeller University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-21866232008-04-17 Prostaglandin E inhibits the production of human interleukin 2 J Exp Med Articles Prostaglandins of the E type specifically inhibited the production of interleukin 2 (IL-2) by normal human lymphocytes, whereas PG synthetase inhibitors such as indomethacin and fentiazac raised IL-2 production above normal levels. Removal of adherent cells from mononuclear cell populations also resulted in enhanced IL-2 production. The resultant nonadherent cell population lost sensitivity to the enhancement effect of PG synthetase inhibitors, suggesting that a PGE-producing adherent cell plays a major role in the regulation of IL-2. The Rockefeller University Press 1982-03-01 /pmc/articles/PMC2186623/ /pubmed/6977613 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
| spellingShingle | Articles Prostaglandin E inhibits the production of human interleukin 2 |
| title | Prostaglandin E inhibits the production of human interleukin 2 |
| title_full | Prostaglandin E inhibits the production of human interleukin 2 |
| title_fullStr | Prostaglandin E inhibits the production of human interleukin 2 |
| title_full_unstemmed | Prostaglandin E inhibits the production of human interleukin 2 |
| title_short | Prostaglandin E inhibits the production of human interleukin 2 |
| title_sort | prostaglandin e inhibits the production of human interleukin 2 |
| topic | Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186623/ https://www.ncbi.nlm.nih.gov/pubmed/6977613 |