Heterozygosity at Gm loci associated with humoral immunity to osteosarcoma

Serum samples from 50 Caucasian patients with osteosarcoma were tested for the presence of antibodies to osteosarcoma-associated antigens (OSAA) and typed for nine Gm markers. A highly significant association was found between Gm 3;5,13,14 and unresponsiveness to OSAA, and between 1,3,17;5,13,14,21...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1982
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186647/
https://www.ncbi.nlm.nih.gov/pubmed/6950023
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collection PubMed
description Serum samples from 50 Caucasian patients with osteosarcoma were tested for the presence of antibodies to osteosarcoma-associated antigens (OSAA) and typed for nine Gm markers. A highly significant association was found between Gm 3;5,13,14 and unresponsiveness to OSAA, and between 1,3,17;5,13,14,21 and responsiveness to OSAA. These results suggest the existence of complementary immune response genes which in the heterozygous condition permit a response to OSAA.
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spelling pubmed-21866472008-04-17 Heterozygosity at Gm loci associated with humoral immunity to osteosarcoma J Exp Med Articles Serum samples from 50 Caucasian patients with osteosarcoma were tested for the presence of antibodies to osteosarcoma-associated antigens (OSAA) and typed for nine Gm markers. A highly significant association was found between Gm 3;5,13,14 and unresponsiveness to OSAA, and between 1,3,17;5,13,14,21 and responsiveness to OSAA. These results suggest the existence of complementary immune response genes which in the heterozygous condition permit a response to OSAA. The Rockefeller University Press 1982-04-01 /pmc/articles/PMC2186647/ /pubmed/6950023 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Heterozygosity at Gm loci associated with humoral immunity to osteosarcoma
title Heterozygosity at Gm loci associated with humoral immunity to osteosarcoma
title_full Heterozygosity at Gm loci associated with humoral immunity to osteosarcoma
title_fullStr Heterozygosity at Gm loci associated with humoral immunity to osteosarcoma
title_full_unstemmed Heterozygosity at Gm loci associated with humoral immunity to osteosarcoma
title_short Heterozygosity at Gm loci associated with humoral immunity to osteosarcoma
title_sort heterozygosity at gm loci associated with humoral immunity to osteosarcoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186647/
https://www.ncbi.nlm.nih.gov/pubmed/6950023

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