Murine interstitial nephritis. I. Analysis of disease susceptibility and its relationship of pleiomorphic gene products defining both immune- response genes and a restrictive requirement for cytotoxic T cells at H- 2K

Anti-tubular basement membrance (alpha TBM) disease-producing interstitial nephritis in mice is not dependent on the generation of alpha TBM antibodies. Susceptibility seems to be defined by very private specificities in H-2K. These specificities are pleiomorphic, providing both immune-response gene...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1982
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186652/
https://www.ncbi.nlm.nih.gov/pubmed/6801184
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description Anti-tubular basement membrance (alpha TBM) disease-producing interstitial nephritis in mice is not dependent on the generation of alpha TBM antibodies. Susceptibility seems to be defined by very private specificities in H-2K. These specificities are pleiomorphic, providing both immune-response genes and identity restrictions for cytotoxic effector functions expressed by a Thy-1.2+, Lyt-2,3+ T cell. These studies establish a role for T cells in the pathogenesis in interstitial nephritis as well as providing further evidence for the role of H-2K in the expression of an autoimmune disease.
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spelling pubmed-21866522008-04-17 Murine interstitial nephritis. I. Analysis of disease susceptibility and its relationship of pleiomorphic gene products defining both immune- response genes and a restrictive requirement for cytotoxic T cells at H- 2K J Exp Med Articles Anti-tubular basement membrance (alpha TBM) disease-producing interstitial nephritis in mice is not dependent on the generation of alpha TBM antibodies. Susceptibility seems to be defined by very private specificities in H-2K. These specificities are pleiomorphic, providing both immune-response genes and identity restrictions for cytotoxic effector functions expressed by a Thy-1.2+, Lyt-2,3+ T cell. These studies establish a role for T cells in the pathogenesis in interstitial nephritis as well as providing further evidence for the role of H-2K in the expression of an autoimmune disease. The Rockefeller University Press 1982-04-01 /pmc/articles/PMC2186652/ /pubmed/6801184 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Murine interstitial nephritis. I. Analysis of disease susceptibility and its relationship of pleiomorphic gene products defining both immune- response genes and a restrictive requirement for cytotoxic T cells at H- 2K
title Murine interstitial nephritis. I. Analysis of disease susceptibility and its relationship of pleiomorphic gene products defining both immune- response genes and a restrictive requirement for cytotoxic T cells at H- 2K
title_full Murine interstitial nephritis. I. Analysis of disease susceptibility and its relationship of pleiomorphic gene products defining both immune- response genes and a restrictive requirement for cytotoxic T cells at H- 2K
title_fullStr Murine interstitial nephritis. I. Analysis of disease susceptibility and its relationship of pleiomorphic gene products defining both immune- response genes and a restrictive requirement for cytotoxic T cells at H- 2K
title_full_unstemmed Murine interstitial nephritis. I. Analysis of disease susceptibility and its relationship of pleiomorphic gene products defining both immune- response genes and a restrictive requirement for cytotoxic T cells at H- 2K
title_short Murine interstitial nephritis. I. Analysis of disease susceptibility and its relationship of pleiomorphic gene products defining both immune- response genes and a restrictive requirement for cytotoxic T cells at H- 2K
title_sort murine interstitial nephritis. i. analysis of disease susceptibility and its relationship of pleiomorphic gene products defining both immune- response genes and a restrictive requirement for cytotoxic t cells at h- 2k
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186652/
https://www.ncbi.nlm.nih.gov/pubmed/6801184

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