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Abrogation by subsequent feeding of antibody response including IgE, in parenterally immunized mice
We have investigated the possibility of oral administration of ovalbumin (OVA) to prevent a secondary antibody response and interrupt reaginic antibody production. Repeated feeding seems necessary for both. Quality of results was dependent on the number of ingestions. Differences in abrogation of an...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1982
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186674/ https://www.ncbi.nlm.nih.gov/pubmed/7069374 |
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collection | PubMed |
description | We have investigated the possibility of oral administration of ovalbumin (OVA) to prevent a secondary antibody response and interrupt reaginic antibody production. Repeated feeding seems necessary for both. Quality of results was dependent on the number of ingestions. Differences in abrogation of antibody response between mice strains were observed. Best results were obtained with AKR mice, good suppression was seen in C3H strain, and inconsistent results were obtained with DBA/2. 10 OVA oral doses were necessary to prevent a secondary antibody response in parenterally immunized mice, but 4 doses interrupted reaginic production in sensitized AKR mice. These results demonstrate that antigen feeding can prevent a secondary antibody response and interrupt reaginic antibody production. |
format | Text |
id | pubmed-2186674 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1982 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21866742008-04-17 Abrogation by subsequent feeding of antibody response including IgE, in parenterally immunized mice J Exp Med Articles We have investigated the possibility of oral administration of ovalbumin (OVA) to prevent a secondary antibody response and interrupt reaginic antibody production. Repeated feeding seems necessary for both. Quality of results was dependent on the number of ingestions. Differences in abrogation of antibody response between mice strains were observed. Best results were obtained with AKR mice, good suppression was seen in C3H strain, and inconsistent results were obtained with DBA/2. 10 OVA oral doses were necessary to prevent a secondary antibody response in parenterally immunized mice, but 4 doses interrupted reaginic production in sensitized AKR mice. These results demonstrate that antigen feeding can prevent a secondary antibody response and interrupt reaginic antibody production. The Rockefeller University Press 1982-05-01 /pmc/articles/PMC2186674/ /pubmed/7069374 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Abrogation by subsequent feeding of antibody response including IgE, in parenterally immunized mice |
title | Abrogation by subsequent feeding of antibody response including IgE, in parenterally immunized mice |
title_full | Abrogation by subsequent feeding of antibody response including IgE, in parenterally immunized mice |
title_fullStr | Abrogation by subsequent feeding of antibody response including IgE, in parenterally immunized mice |
title_full_unstemmed | Abrogation by subsequent feeding of antibody response including IgE, in parenterally immunized mice |
title_short | Abrogation by subsequent feeding of antibody response including IgE, in parenterally immunized mice |
title_sort | abrogation by subsequent feeding of antibody response including ige, in parenterally immunized mice |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186674/ https://www.ncbi.nlm.nih.gov/pubmed/7069374 |