Low dose radiosensitivity of alloimmune cytotoxic T cells

Low dose radiosensitivity of in vitro generated alloimmune murine cytotoxic T lymphocytes (CTL) was studied. It appears that a subset of CTL exists that can be killed with 10-25 rad of x rays. These radiosensitive CTL are Lyt-1,2+ T lymphocytes. Analyses of cytotoxicity by chromium release assays in...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1982
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186704/
https://www.ncbi.nlm.nih.gov/pubmed/6978924
_version_ 1782146004184727552
collection PubMed
description Low dose radiosensitivity of in vitro generated alloimmune murine cytotoxic T lymphocytes (CTL) was studied. It appears that a subset of CTL exists that can be killed with 10-25 rad of x rays. These radiosensitive CTL are Lyt-1,2+ T lymphocytes. Analyses of cytotoxicity by chromium release assays indicate that the radiosensitive CTL are present in responder spleen cell cultures from all strains of mice tested. The generation of these effector cells is most pronounced in animals of the C57BL background. The mechanism of low dose radiosensitivity appears to be interphase death.
format Text
id pubmed-2186704
institution National Center for Biotechnology Information
language English
publishDate 1982
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21867042008-04-17 Low dose radiosensitivity of alloimmune cytotoxic T cells J Exp Med Articles Low dose radiosensitivity of in vitro generated alloimmune murine cytotoxic T lymphocytes (CTL) was studied. It appears that a subset of CTL exists that can be killed with 10-25 rad of x rays. These radiosensitive CTL are Lyt-1,2+ T lymphocytes. Analyses of cytotoxicity by chromium release assays indicate that the radiosensitive CTL are present in responder spleen cell cultures from all strains of mice tested. The generation of these effector cells is most pronounced in animals of the C57BL background. The mechanism of low dose radiosensitivity appears to be interphase death. The Rockefeller University Press 1982-06-01 /pmc/articles/PMC2186704/ /pubmed/6978924 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Low dose radiosensitivity of alloimmune cytotoxic T cells
title Low dose radiosensitivity of alloimmune cytotoxic T cells
title_full Low dose radiosensitivity of alloimmune cytotoxic T cells
title_fullStr Low dose radiosensitivity of alloimmune cytotoxic T cells
title_full_unstemmed Low dose radiosensitivity of alloimmune cytotoxic T cells
title_short Low dose radiosensitivity of alloimmune cytotoxic T cells
title_sort low dose radiosensitivity of alloimmune cytotoxic t cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186704/
https://www.ncbi.nlm.nih.gov/pubmed/6978924

Ejemplares similares