Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes

The specificity repertoire of H-2Kb-specific cytolytic T lymphocytes (CTL) has been examined in B10.D2,BALB/c, and the allotype congenic line CB-20. Comparing their expression of recurrent specificities that serve as markers for the repertoire of each strain indicates that the CTL repertoire of B10....

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1982
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186724/
https://www.ncbi.nlm.nih.gov/pubmed/6177825
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description The specificity repertoire of H-2Kb-specific cytolytic T lymphocytes (CTL) has been examined in B10.D2,BALB/c, and the allotype congenic line CB-20. Comparing their expression of recurrent specificities that serve as markers for the repertoire of each strain indicates that the CTL repertoire of B10.D2 (Ighb) and BALB/c (Igha) differ extensively. In contrast, the repertoires expressed by B10.D2 and CB-20 (Ighb) are essentially identical with respect to their expression of the same recurrent specificities. Taken together with results previously obtained, it is concluded that both major histocompatibility complex and Igh-linked genes affect the CTL specificity repertoire.
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spelling pubmed-21867242008-04-17 Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes J Exp Med Articles The specificity repertoire of H-2Kb-specific cytolytic T lymphocytes (CTL) has been examined in B10.D2,BALB/c, and the allotype congenic line CB-20. Comparing their expression of recurrent specificities that serve as markers for the repertoire of each strain indicates that the CTL repertoire of B10.D2 (Ighb) and BALB/c (Igha) differ extensively. In contrast, the repertoires expressed by B10.D2 and CB-20 (Ighb) are essentially identical with respect to their expression of the same recurrent specificities. Taken together with results previously obtained, it is concluded that both major histocompatibility complex and Igh-linked genes affect the CTL specificity repertoire. The Rockefeller University Press 1982-07-01 /pmc/articles/PMC2186724/ /pubmed/6177825 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes
title Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes
title_full Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes
title_fullStr Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes
title_full_unstemmed Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes
title_short Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes
title_sort genetic linkage of the cytolytic t lymphocyte repertoire and immunoglobulin heavy chain genes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186724/
https://www.ncbi.nlm.nih.gov/pubmed/6177825

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