A monoclonal T cell-replacing activity can act directly on B cells to enhance clonal expansion

We have used a B cell cloning system in which the response of a single isolated B cell to lipopolysaccharide and dextran sulfide can be followed. We have shown that culture supernatants from the Dennert long- term alloreactive T cell line C.C3.11.75 increase the frequency of B cells stimulated to cl...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1982
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186738/
https://www.ncbi.nlm.nih.gov/pubmed/6979606
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collection PubMed
description We have used a B cell cloning system in which the response of a single isolated B cell to lipopolysaccharide and dextran sulfide can be followed. We have shown that culture supernatants from the Dennert long- term alloreactive T cell line C.C3.11.75 increase the frequency of B cells stimulated to clonal expansion by mitogens. These culture supernatants are devoid of interleukin 1 and 2 but contain the T cell- replacing factor activity (DL)TRF. These experiments provide unequivocal proof that a T cell-derived factor or factors can act directly on a B lymphocyte in the absence of any other cell.
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spelling pubmed-21867382008-04-17 A monoclonal T cell-replacing activity can act directly on B cells to enhance clonal expansion J Exp Med Articles We have used a B cell cloning system in which the response of a single isolated B cell to lipopolysaccharide and dextran sulfide can be followed. We have shown that culture supernatants from the Dennert long- term alloreactive T cell line C.C3.11.75 increase the frequency of B cells stimulated to clonal expansion by mitogens. These culture supernatants are devoid of interleukin 1 and 2 but contain the T cell- replacing factor activity (DL)TRF. These experiments provide unequivocal proof that a T cell-derived factor or factors can act directly on a B lymphocyte in the absence of any other cell. The Rockefeller University Press 1982-07-01 /pmc/articles/PMC2186738/ /pubmed/6979606 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
A monoclonal T cell-replacing activity can act directly on B cells to enhance clonal expansion
title A monoclonal T cell-replacing activity can act directly on B cells to enhance clonal expansion
title_full A monoclonal T cell-replacing activity can act directly on B cells to enhance clonal expansion
title_fullStr A monoclonal T cell-replacing activity can act directly on B cells to enhance clonal expansion
title_full_unstemmed A monoclonal T cell-replacing activity can act directly on B cells to enhance clonal expansion
title_short A monoclonal T cell-replacing activity can act directly on B cells to enhance clonal expansion
title_sort monoclonal t cell-replacing activity can act directly on b cells to enhance clonal expansion
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186738/
https://www.ncbi.nlm.nih.gov/pubmed/6979606

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