Demonstration of a third structurally distinct human Ia beta chain by two-dimensional gel electrophoresis

Previous studies have indicated that HLA-DR homozygous cell lines express two Ia alpha and Ia beta chains that combine to form at least two Ia molecules. This report demonstrates by two-dimensional gel electrophoresis the existence of a third structurally distinct human Ia beta chain on DR2 and DR5...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1982
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186752/
https://www.ncbi.nlm.nih.gov/pubmed/6980260
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collection PubMed
description Previous studies have indicated that HLA-DR homozygous cell lines express two Ia alpha and Ia beta chains that combine to form at least two Ia molecules. This report demonstrates by two-dimensional gel electrophoresis the existence of a third structurally distinct human Ia beta chain on DR2 and DR5 cell lines. This suggests that at least five separate genes control the expression of Ia molecules on HLA-DR homozygous cell lines.
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spelling pubmed-21867522008-04-17 Demonstration of a third structurally distinct human Ia beta chain by two-dimensional gel electrophoresis J Exp Med Articles Previous studies have indicated that HLA-DR homozygous cell lines express two Ia alpha and Ia beta chains that combine to form at least two Ia molecules. This report demonstrates by two-dimensional gel electrophoresis the existence of a third structurally distinct human Ia beta chain on DR2 and DR5 cell lines. This suggests that at least five separate genes control the expression of Ia molecules on HLA-DR homozygous cell lines. The Rockefeller University Press 1982-08-01 /pmc/articles/PMC2186752/ /pubmed/6980260 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Demonstration of a third structurally distinct human Ia beta chain by two-dimensional gel electrophoresis
title Demonstration of a third structurally distinct human Ia beta chain by two-dimensional gel electrophoresis
title_full Demonstration of a third structurally distinct human Ia beta chain by two-dimensional gel electrophoresis
title_fullStr Demonstration of a third structurally distinct human Ia beta chain by two-dimensional gel electrophoresis
title_full_unstemmed Demonstration of a third structurally distinct human Ia beta chain by two-dimensional gel electrophoresis
title_short Demonstration of a third structurally distinct human Ia beta chain by two-dimensional gel electrophoresis
title_sort demonstration of a third structurally distinct human ia beta chain by two-dimensional gel electrophoresis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186752/
https://www.ncbi.nlm.nih.gov/pubmed/6980260

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