Mutant monoclonal antibodies with alterations in biological functions

Somatic cell mutants with deletions in the immunoglobulin constant region were isolated from an IgG(2b) Ar-binding hybridoma. Rat anti-mouse immunoglobulins were used to identify the sites of the deletions. The mutant monoclonal antibodies differ from the parental molecule in their assembly states a...

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Detalles Bibliográficos
Autores principales: Yelton, DE, Scharff, MD
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1982
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186830/
https://www.ncbi.nlm.nih.gov/pubmed/6818317
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author Yelton, DE
Scharff, MD
author_facet Yelton, DE
Scharff, MD
author_sort Yelton, DE
collection PubMed
description Somatic cell mutants with deletions in the immunoglobulin constant region were isolated from an IgG(2b) Ar-binding hybridoma. Rat anti-mouse immunoglobulins were used to identify the sites of the deletions. The mutant monoclonal antibodies differ from the parental molecule in their assembly states and are defective in various immunoglobulin activities, making them potentially more useful reagents.
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spelling pubmed-21868302008-04-17 Mutant monoclonal antibodies with alterations in biological functions Yelton, DE Scharff, MD J Exp Med Articles Somatic cell mutants with deletions in the immunoglobulin constant region were isolated from an IgG(2b) Ar-binding hybridoma. Rat anti-mouse immunoglobulins were used to identify the sites of the deletions. The mutant monoclonal antibodies differ from the parental molecule in their assembly states and are defective in various immunoglobulin activities, making them potentially more useful reagents. The Rockefeller University Press 1982-10-01 /pmc/articles/PMC2186830/ /pubmed/6818317 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Yelton, DE
Scharff, MD
Mutant monoclonal antibodies with alterations in biological functions
title Mutant monoclonal antibodies with alterations in biological functions
title_full Mutant monoclonal antibodies with alterations in biological functions
title_fullStr Mutant monoclonal antibodies with alterations in biological functions
title_full_unstemmed Mutant monoclonal antibodies with alterations in biological functions
title_short Mutant monoclonal antibodies with alterations in biological functions
title_sort mutant monoclonal antibodies with alterations in biological functions
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186830/
https://www.ncbi.nlm.nih.gov/pubmed/6818317
work_keys_str_mv AT yeltonde mutantmonoclonalantibodieswithalterationsinbiologicalfunctions
AT scharffmd mutantmonoclonalantibodieswithalterationsinbiologicalfunctions

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