Primary cell-mediated lympholysis response to a maternally transmitted antigen

Mta-specific cytotoxic T lymphocyte (CTL) can be generated in primary cultures of (NZB X B10.D2)F1 spleen cells with H-2-compatible BALB/c stimulator cells. The CTL lyse reciprocal Mta+ (B10.D2 X NZB)F1 as well as H-2-disparate targets, such as B10, B6, and B6-Tlaa; they do not lyse targets from NZB...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1982
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186876/
https://www.ncbi.nlm.nih.gov/pubmed/6983563
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collection PubMed
description Mta-specific cytotoxic T lymphocyte (CTL) can be generated in primary cultures of (NZB X B10.D2)F1 spleen cells with H-2-compatible BALB/c stimulator cells. The CTL lyse reciprocal Mta+ (B10.D2 X NZB)F1 as well as H-2-disparate targets, such as B10, B6, and B6-Tlaa; they do not lyse targets from NZB or any F1 hybrid of an NZB mother. The lysis of 51Cr-labeled B10 targets is completely inhibited by unlabeled targets from Mta+ (B10.D2 X NZB)F1, but not from the reciprocal Mta- F1, thus demonstrating H-2-unrestricted lysis of Mta.
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spelling pubmed-21868762008-04-17 Primary cell-mediated lympholysis response to a maternally transmitted antigen J Exp Med Articles Mta-specific cytotoxic T lymphocyte (CTL) can be generated in primary cultures of (NZB X B10.D2)F1 spleen cells with H-2-compatible BALB/c stimulator cells. The CTL lyse reciprocal Mta+ (B10.D2 X NZB)F1 as well as H-2-disparate targets, such as B10, B6, and B6-Tlaa; they do not lyse targets from NZB or any F1 hybrid of an NZB mother. The lysis of 51Cr-labeled B10 targets is completely inhibited by unlabeled targets from Mta+ (B10.D2 X NZB)F1, but not from the reciprocal Mta- F1, thus demonstrating H-2-unrestricted lysis of Mta. The Rockefeller University Press 1982-12-01 /pmc/articles/PMC2186876/ /pubmed/6983563 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Primary cell-mediated lympholysis response to a maternally transmitted antigen
title Primary cell-mediated lympholysis response to a maternally transmitted antigen
title_full Primary cell-mediated lympholysis response to a maternally transmitted antigen
title_fullStr Primary cell-mediated lympholysis response to a maternally transmitted antigen
title_full_unstemmed Primary cell-mediated lympholysis response to a maternally transmitted antigen
title_short Primary cell-mediated lympholysis response to a maternally transmitted antigen
title_sort primary cell-mediated lympholysis response to a maternally transmitted antigen
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186876/
https://www.ncbi.nlm.nih.gov/pubmed/6983563

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