Macrophage activation selectively enhances expression of Fc receptors for IgG2a

After infection with bacillus Calmette-Guerin, peritoneal macrophages (Mo) display enhanced expression of FcR for both monomeric and complexed IgG2a, but not IgG2b. Isotype specificity of FcR can be reversed on nonactivated Mo by immune lymphokines, and IgG2a immune complexes are more effective trig...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1983
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186936/
https://www.ncbi.nlm.nih.gov/pubmed/6822787
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collection PubMed
description After infection with bacillus Calmette-Guerin, peritoneal macrophages (Mo) display enhanced expression of FcR for both monomeric and complexed IgG2a, but not IgG2b. Isotype specificity of FcR can be reversed on nonactivated Mo by immune lymphokines, and IgG2a immune complexes are more effective triggers of the respiratory burst in activated Mo. Selective enhancement of IgG2a FcR by Mo activation could account for efficacy of homologous ab in mediating cytotoxicity in some systems.
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spelling pubmed-21869362008-04-17 Macrophage activation selectively enhances expression of Fc receptors for IgG2a J Exp Med Articles After infection with bacillus Calmette-Guerin, peritoneal macrophages (Mo) display enhanced expression of FcR for both monomeric and complexed IgG2a, but not IgG2b. Isotype specificity of FcR can be reversed on nonactivated Mo by immune lymphokines, and IgG2a immune complexes are more effective triggers of the respiratory burst in activated Mo. Selective enhancement of IgG2a FcR by Mo activation could account for efficacy of homologous ab in mediating cytotoxicity in some systems. The Rockefeller University Press 1983-02-01 /pmc/articles/PMC2186936/ /pubmed/6822787 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Macrophage activation selectively enhances expression of Fc receptors for IgG2a
title Macrophage activation selectively enhances expression of Fc receptors for IgG2a
title_full Macrophage activation selectively enhances expression of Fc receptors for IgG2a
title_fullStr Macrophage activation selectively enhances expression of Fc receptors for IgG2a
title_full_unstemmed Macrophage activation selectively enhances expression of Fc receptors for IgG2a
title_short Macrophage activation selectively enhances expression of Fc receptors for IgG2a
title_sort macrophage activation selectively enhances expression of fc receptors for igg2a
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186936/
https://www.ncbi.nlm.nih.gov/pubmed/6822787

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