Fine specificity of idiotope suppression in the A/J anti- azophenylarsonate response

Two hapten-inhibitable murine monoclonal antiidiotopic antibodies identified two idiotopes expressed by the heavy chain of hybridoma protein 36-65, whose amino acid sequence is encoded in the germ line of A/J mice. Among cross-reactive idiotype-positive hybridoma proteins and p-azophenylarsonate-imm...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1983
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186940/
https://www.ncbi.nlm.nih.gov/pubmed/6185619
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collection PubMed
description Two hapten-inhibitable murine monoclonal antiidiotopic antibodies identified two idiotopes expressed by the heavy chain of hybridoma protein 36-65, whose amino acid sequence is encoded in the germ line of A/J mice. Among cross-reactive idiotype-positive hybridoma proteins and p-azophenylarsonate-immune antibodies, the two idiotopes were not always expressed together; some diversified antibodies expressed one idiotope without the other. Suppression that was induced by the two antiidiotopes was idiotope specific and corresponded to the fine specificities of these two reagents.
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spelling pubmed-21869402008-04-17 Fine specificity of idiotope suppression in the A/J anti- azophenylarsonate response J Exp Med Articles Two hapten-inhibitable murine monoclonal antiidiotopic antibodies identified two idiotopes expressed by the heavy chain of hybridoma protein 36-65, whose amino acid sequence is encoded in the germ line of A/J mice. Among cross-reactive idiotype-positive hybridoma proteins and p-azophenylarsonate-immune antibodies, the two idiotopes were not always expressed together; some diversified antibodies expressed one idiotope without the other. Suppression that was induced by the two antiidiotopes was idiotope specific and corresponded to the fine specificities of these two reagents. The Rockefeller University Press 1983-02-01 /pmc/articles/PMC2186940/ /pubmed/6185619 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Fine specificity of idiotope suppression in the A/J anti- azophenylarsonate response
title Fine specificity of idiotope suppression in the A/J anti- azophenylarsonate response
title_full Fine specificity of idiotope suppression in the A/J anti- azophenylarsonate response
title_fullStr Fine specificity of idiotope suppression in the A/J anti- azophenylarsonate response
title_full_unstemmed Fine specificity of idiotope suppression in the A/J anti- azophenylarsonate response
title_short Fine specificity of idiotope suppression in the A/J anti- azophenylarsonate response
title_sort fine specificity of idiotope suppression in the a/j anti- azophenylarsonate response
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186940/
https://www.ncbi.nlm.nih.gov/pubmed/6185619

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