The activity of natural cytotoxic cells is augmented by interleukin 2 and interleukin 3

Murine natural killer (NK) and natural cytotoxic (NC) cells showed different patterns of augmentation of lytic activity after preincubation for 24 h with either poly-IC, interleukin 2 (IL-2), or interleukin 3 (IL-3): (a) Poly-IC augmented only NK cells, with no effect on NC activity, as we have prev...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1983
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186950/
https://www.ncbi.nlm.nih.gov/pubmed/6403648
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description Murine natural killer (NK) and natural cytotoxic (NC) cells showed different patterns of augmentation of lytic activity after preincubation for 24 h with either poly-IC, interleukin 2 (IL-2), or interleukin 3 (IL-3): (a) Poly-IC augmented only NK cells, with no effect on NC activity, as we have previously observed (4); (b) IL-2 augmented both NK and NC activity; and (c) IL-3 augmented only NC lysis, without affecting NK activity. In addition, both precursor and the augmented effector cells showed differences in expression of the Qa- 5 surface marker: NK precursors and effectors are Qa 5+, whereas NC precursors and effector cells are Qa-5-.
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spelling pubmed-21869502008-04-17 The activity of natural cytotoxic cells is augmented by interleukin 2 and interleukin 3 J Exp Med Articles Murine natural killer (NK) and natural cytotoxic (NC) cells showed different patterns of augmentation of lytic activity after preincubation for 24 h with either poly-IC, interleukin 2 (IL-2), or interleukin 3 (IL-3): (a) Poly-IC augmented only NK cells, with no effect on NC activity, as we have previously observed (4); (b) IL-2 augmented both NK and NC activity; and (c) IL-3 augmented only NC lysis, without affecting NK activity. In addition, both precursor and the augmented effector cells showed differences in expression of the Qa- 5 surface marker: NK precursors and effectors are Qa 5+, whereas NC precursors and effector cells are Qa-5-. The Rockefeller University Press 1983-03-01 /pmc/articles/PMC2186950/ /pubmed/6403648 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
The activity of natural cytotoxic cells is augmented by interleukin 2 and interleukin 3
title The activity of natural cytotoxic cells is augmented by interleukin 2 and interleukin 3
title_full The activity of natural cytotoxic cells is augmented by interleukin 2 and interleukin 3
title_fullStr The activity of natural cytotoxic cells is augmented by interleukin 2 and interleukin 3
title_full_unstemmed The activity of natural cytotoxic cells is augmented by interleukin 2 and interleukin 3
title_short The activity of natural cytotoxic cells is augmented by interleukin 2 and interleukin 3
title_sort activity of natural cytotoxic cells is augmented by interleukin 2 and interleukin 3
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186950/
https://www.ncbi.nlm.nih.gov/pubmed/6403648

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