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Secretion of a proteolytic anticoagulant by Ancylostoma hookworms
Hookworms of the genus Ancylostoma secrete an anticoagulant that both inhibits the clotting of human plasma and promotes fibrin clot dissolution. This anticoagulant activity is attributable to a 36,000 dalton proteolytic enzyme. The protease can degrade fibrinogen into five smaller polypeptides that...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1983
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186995/ https://www.ncbi.nlm.nih.gov/pubmed/6343546 |
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collection | PubMed |
description | Hookworms of the genus Ancylostoma secrete an anticoagulant that both inhibits the clotting of human plasma and promotes fibrin clot dissolution. This anticoagulant activity is attributable to a 36,000 dalton proteolytic enzyme. The protease can degrade fibrinogen into five smaller polypeptides that intrinsically have anticoagulating properties, covert plasminogen to a mini-plasminogen-like molecule, and hydrolyze a synthetic peptide substrate with specificity for elastolytic enzymes. It is hypothesized that the parasite uses this enzyme to prevent blood clotting while feeding on villous capillaries. |
format | Text |
id | pubmed-2186995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1983 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21869952008-04-17 Secretion of a proteolytic anticoagulant by Ancylostoma hookworms J Exp Med Articles Hookworms of the genus Ancylostoma secrete an anticoagulant that both inhibits the clotting of human plasma and promotes fibrin clot dissolution. This anticoagulant activity is attributable to a 36,000 dalton proteolytic enzyme. The protease can degrade fibrinogen into five smaller polypeptides that intrinsically have anticoagulating properties, covert plasminogen to a mini-plasminogen-like molecule, and hydrolyze a synthetic peptide substrate with specificity for elastolytic enzymes. It is hypothesized that the parasite uses this enzyme to prevent blood clotting while feeding on villous capillaries. The Rockefeller University Press 1983-05-01 /pmc/articles/PMC2186995/ /pubmed/6343546 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Secretion of a proteolytic anticoagulant by Ancylostoma hookworms |
title | Secretion of a proteolytic anticoagulant by Ancylostoma hookworms |
title_full | Secretion of a proteolytic anticoagulant by Ancylostoma hookworms |
title_fullStr | Secretion of a proteolytic anticoagulant by Ancylostoma hookworms |
title_full_unstemmed | Secretion of a proteolytic anticoagulant by Ancylostoma hookworms |
title_short | Secretion of a proteolytic anticoagulant by Ancylostoma hookworms |
title_sort | secretion of a proteolytic anticoagulant by ancylostoma hookworms |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186995/ https://www.ncbi.nlm.nih.gov/pubmed/6343546 |