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Secretion of a proteolytic anticoagulant by Ancylostoma hookworms

Hookworms of the genus Ancylostoma secrete an anticoagulant that both inhibits the clotting of human plasma and promotes fibrin clot dissolution. This anticoagulant activity is attributable to a 36,000 dalton proteolytic enzyme. The protease can degrade fibrinogen into five smaller polypeptides that...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1983
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186995/
https://www.ncbi.nlm.nih.gov/pubmed/6343546
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description Hookworms of the genus Ancylostoma secrete an anticoagulant that both inhibits the clotting of human plasma and promotes fibrin clot dissolution. This anticoagulant activity is attributable to a 36,000 dalton proteolytic enzyme. The protease can degrade fibrinogen into five smaller polypeptides that intrinsically have anticoagulating properties, covert plasminogen to a mini-plasminogen-like molecule, and hydrolyze a synthetic peptide substrate with specificity for elastolytic enzymes. It is hypothesized that the parasite uses this enzyme to prevent blood clotting while feeding on villous capillaries.
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spelling pubmed-21869952008-04-17 Secretion of a proteolytic anticoagulant by Ancylostoma hookworms J Exp Med Articles Hookworms of the genus Ancylostoma secrete an anticoagulant that both inhibits the clotting of human plasma and promotes fibrin clot dissolution. This anticoagulant activity is attributable to a 36,000 dalton proteolytic enzyme. The protease can degrade fibrinogen into five smaller polypeptides that intrinsically have anticoagulating properties, covert plasminogen to a mini-plasminogen-like molecule, and hydrolyze a synthetic peptide substrate with specificity for elastolytic enzymes. It is hypothesized that the parasite uses this enzyme to prevent blood clotting while feeding on villous capillaries. The Rockefeller University Press 1983-05-01 /pmc/articles/PMC2186995/ /pubmed/6343546 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Secretion of a proteolytic anticoagulant by Ancylostoma hookworms
title Secretion of a proteolytic anticoagulant by Ancylostoma hookworms
title_full Secretion of a proteolytic anticoagulant by Ancylostoma hookworms
title_fullStr Secretion of a proteolytic anticoagulant by Ancylostoma hookworms
title_full_unstemmed Secretion of a proteolytic anticoagulant by Ancylostoma hookworms
title_short Secretion of a proteolytic anticoagulant by Ancylostoma hookworms
title_sort secretion of a proteolytic anticoagulant by ancylostoma hookworms
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186995/
https://www.ncbi.nlm.nih.gov/pubmed/6343546