Functionally restricted, allospecific, human helper T cell lines that amplify either B cell or cytolytic T cell responses

Using a panel of partially cloned, OKT4+, DRw-1-specific, alloproliferative human T cell lines, we have identified two functionally restricted and reciprocating types of helper T cells. One provides major histocompatibility complex-restricted help for plaque- forming cell responses by DRw 1+ allogen...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1983
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187003/
https://www.ncbi.nlm.nih.gov/pubmed/6189944
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collection PubMed
description Using a panel of partially cloned, OKT4+, DRw-1-specific, alloproliferative human T cell lines, we have identified two functionally restricted and reciprocating types of helper T cells. One provides major histocompatibility complex-restricted help for plaque- forming cell responses by DRw 1+ allogeneic B cells; the other preferentially amplifies the generation of allospecific cytotoxic T lymphocytes (CTL) from CTL precursors that have been suboptimally triggered by alloantigen.
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spelling pubmed-21870032008-04-17 Functionally restricted, allospecific, human helper T cell lines that amplify either B cell or cytolytic T cell responses J Exp Med Articles Using a panel of partially cloned, OKT4+, DRw-1-specific, alloproliferative human T cell lines, we have identified two functionally restricted and reciprocating types of helper T cells. One provides major histocompatibility complex-restricted help for plaque- forming cell responses by DRw 1+ allogeneic B cells; the other preferentially amplifies the generation of allospecific cytotoxic T lymphocytes (CTL) from CTL precursors that have been suboptimally triggered by alloantigen. The Rockefeller University Press 1983-05-01 /pmc/articles/PMC2187003/ /pubmed/6189944 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Functionally restricted, allospecific, human helper T cell lines that amplify either B cell or cytolytic T cell responses
title Functionally restricted, allospecific, human helper T cell lines that amplify either B cell or cytolytic T cell responses
title_full Functionally restricted, allospecific, human helper T cell lines that amplify either B cell or cytolytic T cell responses
title_fullStr Functionally restricted, allospecific, human helper T cell lines that amplify either B cell or cytolytic T cell responses
title_full_unstemmed Functionally restricted, allospecific, human helper T cell lines that amplify either B cell or cytolytic T cell responses
title_short Functionally restricted, allospecific, human helper T cell lines that amplify either B cell or cytolytic T cell responses
title_sort functionally restricted, allospecific, human helper t cell lines that amplify either b cell or cytolytic t cell responses
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187003/
https://www.ncbi.nlm.nih.gov/pubmed/6189944

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