Identification, purification, and characterization of antigen-activated and antigen-specific human B lymphocytes

Activated pneumococcal polysaccharide (PPS)-specific human B lymphocytes have been purified and examined in vitro. They are large cells that are refractory to further activation by antigen, anti-Ig, or Staphylococcus aureus Cowan strain I, but they respond directly by proliferation to B cell growth...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1983
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187019/
https://www.ncbi.nlm.nih.gov/pubmed/6189946
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collection PubMed
description Activated pneumococcal polysaccharide (PPS)-specific human B lymphocytes have been purified and examined in vitro. They are large cells that are refractory to further activation by antigen, anti-Ig, or Staphylococcus aureus Cowan strain I, but they respond directly by proliferation to B cell growth factors. In addition, they express the isotype pattern of activated cells and a surface marker of activated lymphocytes called 4F2. Finally, they contain a subset of cells that spontaneously secrete PPS-specific antibody.
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spelling pubmed-21870192008-04-17 Identification, purification, and characterization of antigen-activated and antigen-specific human B lymphocytes J Exp Med Articles Activated pneumococcal polysaccharide (PPS)-specific human B lymphocytes have been purified and examined in vitro. They are large cells that are refractory to further activation by antigen, anti-Ig, or Staphylococcus aureus Cowan strain I, but they respond directly by proliferation to B cell growth factors. In addition, they express the isotype pattern of activated cells and a surface marker of activated lymphocytes called 4F2. Finally, they contain a subset of cells that spontaneously secrete PPS-specific antibody. The Rockefeller University Press 1983-05-01 /pmc/articles/PMC2187019/ /pubmed/6189946 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Identification, purification, and characterization of antigen-activated and antigen-specific human B lymphocytes
title Identification, purification, and characterization of antigen-activated and antigen-specific human B lymphocytes
title_full Identification, purification, and characterization of antigen-activated and antigen-specific human B lymphocytes
title_fullStr Identification, purification, and characterization of antigen-activated and antigen-specific human B lymphocytes
title_full_unstemmed Identification, purification, and characterization of antigen-activated and antigen-specific human B lymphocytes
title_short Identification, purification, and characterization of antigen-activated and antigen-specific human B lymphocytes
title_sort identification, purification, and characterization of antigen-activated and antigen-specific human b lymphocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187019/
https://www.ncbi.nlm.nih.gov/pubmed/6189946

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