Structural heterogeneity of the C3b/C4b receptor (Cr 1) on human peripheral blood cells

In these studies CR 1 polymorphism previously demonstrated on erythrocytes (E) was also found on CR 1-bearing peripheral blood leukocytes including polymorphonuclear (PMN), eosinophils, monocytes, and B lymphocytes. However several cell-specific differences in CR1 were found: (a) an approximately 5,...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1983
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187053/
https://www.ncbi.nlm.nih.gov/pubmed/6222138
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description In these studies CR 1 polymorphism previously demonstrated on erythrocytes (E) was also found on CR 1-bearing peripheral blood leukocytes including polymorphonuclear (PMN), eosinophils, monocytes, and B lymphocytes. However several cell-specific differences in CR1 were found: (a) an approximately 5,000-dalton increase in CR 1 on PMN and eosinophils, (b) unequal band intensity among heterozygotes suggests that there is preferential expression of 220,000- or 225,000- dalton receptors on leukocytes compared to E, and (c) "minor" bands, approximately 15,000 daltons larger than the major receptor molecule, were found on E but not on leukocytes. These observations constitute a unique example of heterogeneity of an integral membrane receptor.
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spelling pubmed-21870532008-04-17 Structural heterogeneity of the C3b/C4b receptor (Cr 1) on human peripheral blood cells J Exp Med Articles In these studies CR 1 polymorphism previously demonstrated on erythrocytes (E) was also found on CR 1-bearing peripheral blood leukocytes including polymorphonuclear (PMN), eosinophils, monocytes, and B lymphocytes. However several cell-specific differences in CR1 were found: (a) an approximately 5,000-dalton increase in CR 1 on PMN and eosinophils, (b) unequal band intensity among heterozygotes suggests that there is preferential expression of 220,000- or 225,000- dalton receptors on leukocytes compared to E, and (c) "minor" bands, approximately 15,000 daltons larger than the major receptor molecule, were found on E but not on leukocytes. These observations constitute a unique example of heterogeneity of an integral membrane receptor. The Rockefeller University Press 1983-06-01 /pmc/articles/PMC2187053/ /pubmed/6222138 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Structural heterogeneity of the C3b/C4b receptor (Cr 1) on human peripheral blood cells
title Structural heterogeneity of the C3b/C4b receptor (Cr 1) on human peripheral blood cells
title_full Structural heterogeneity of the C3b/C4b receptor (Cr 1) on human peripheral blood cells
title_fullStr Structural heterogeneity of the C3b/C4b receptor (Cr 1) on human peripheral blood cells
title_full_unstemmed Structural heterogeneity of the C3b/C4b receptor (Cr 1) on human peripheral blood cells
title_short Structural heterogeneity of the C3b/C4b receptor (Cr 1) on human peripheral blood cells
title_sort structural heterogeneity of the c3b/c4b receptor (cr 1) on human peripheral blood cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187053/
https://www.ncbi.nlm.nih.gov/pubmed/6222138

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