Complement receptor mediates enhanced flavivirus replication in macrophages

Evidence is presented that M phi complement receptors (CR3) mediate IgM- dependent enhancement of flavivirus replication in the presence of complement. Enhancement is blocked by pretreatment of macrophages with monoclonal antibody Ml/70, which inhibits CR3 binding, but not by pretreatment with monoc...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1983
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187083/
https://www.ncbi.nlm.nih.gov/pubmed/6864163
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collection PubMed
description Evidence is presented that M phi complement receptors (CR3) mediate IgM- dependent enhancement of flavivirus replication in the presence of complement. Enhancement is blocked by pretreatment of macrophages with monoclonal antibody Ml/70, which inhibits CR3 binding, but not by pretreatment with monoclonal antibody 2.4G2, which inhibits FcR binding.
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spelling pubmed-21870832008-04-17 Complement receptor mediates enhanced flavivirus replication in macrophages J Exp Med Articles Evidence is presented that M phi complement receptors (CR3) mediate IgM- dependent enhancement of flavivirus replication in the presence of complement. Enhancement is blocked by pretreatment of macrophages with monoclonal antibody Ml/70, which inhibits CR3 binding, but not by pretreatment with monoclonal antibody 2.4G2, which inhibits FcR binding. The Rockefeller University Press 1983-07-01 /pmc/articles/PMC2187083/ /pubmed/6864163 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Complement receptor mediates enhanced flavivirus replication in macrophages
title Complement receptor mediates enhanced flavivirus replication in macrophages
title_full Complement receptor mediates enhanced flavivirus replication in macrophages
title_fullStr Complement receptor mediates enhanced flavivirus replication in macrophages
title_full_unstemmed Complement receptor mediates enhanced flavivirus replication in macrophages
title_short Complement receptor mediates enhanced flavivirus replication in macrophages
title_sort complement receptor mediates enhanced flavivirus replication in macrophages
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187083/
https://www.ncbi.nlm.nih.gov/pubmed/6864163

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