Cell membrane perturbation of resting T cells and thymocytes causes display of activation antigens

Three human lymphocyte antigens recognized by monoclonal antibodies OKIa1, OKT9, and OKT10 were found to be minimally represented on resting peripheral T cells (all three) and thymocytes (OKIa1 and OKT9). These antigens, which are present on "activated" T cells, were promptly displayed on...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1983
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187085/
https://www.ncbi.nlm.nih.gov/pubmed/6345715
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description Three human lymphocyte antigens recognized by monoclonal antibodies OKIa1, OKT9, and OKT10 were found to be minimally represented on resting peripheral T cells (all three) and thymocytes (OKIa1 and OKT9). These antigens, which are present on "activated" T cells, were promptly displayed on "resting" T cells or thymocytes following cross-linking of surface-bound monoclonal antibody by horse alpha-mouse IgG. These experiments suggested that membrane perturbations may induce the expression of certain antigens that are normally present in an unexpressed form in resting cells.
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spelling pubmed-21870852008-04-17 Cell membrane perturbation of resting T cells and thymocytes causes display of activation antigens J Exp Med Articles Three human lymphocyte antigens recognized by monoclonal antibodies OKIa1, OKT9, and OKT10 were found to be minimally represented on resting peripheral T cells (all three) and thymocytes (OKIa1 and OKT9). These antigens, which are present on "activated" T cells, were promptly displayed on "resting" T cells or thymocytes following cross-linking of surface-bound monoclonal antibody by horse alpha-mouse IgG. These experiments suggested that membrane perturbations may induce the expression of certain antigens that are normally present in an unexpressed form in resting cells. The Rockefeller University Press 1983-07-01 /pmc/articles/PMC2187085/ /pubmed/6345715 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Cell membrane perturbation of resting T cells and thymocytes causes display of activation antigens
title Cell membrane perturbation of resting T cells and thymocytes causes display of activation antigens
title_full Cell membrane perturbation of resting T cells and thymocytes causes display of activation antigens
title_fullStr Cell membrane perturbation of resting T cells and thymocytes causes display of activation antigens
title_full_unstemmed Cell membrane perturbation of resting T cells and thymocytes causes display of activation antigens
title_short Cell membrane perturbation of resting T cells and thymocytes causes display of activation antigens
title_sort cell membrane perturbation of resting t cells and thymocytes causes display of activation antigens
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187085/
https://www.ncbi.nlm.nih.gov/pubmed/6345715

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