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Antibodies to normal human melanocytes in vitiligo
Most patients with active vitiligo (82% of 61) have antibodies to antigens of normal human melanocytes that can be detected by specific immunoprecipitation of radioiodinated, detergent-soluble, melanocyte macromolecules. Such antibodies were present in only 12% of patients with melanoma and in none...
| Formato: | Texto |
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| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1983
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187087/ https://www.ncbi.nlm.nih.gov/pubmed/6345714 |
| _version_ | 1782146092985483264 |
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| collection | PubMed |
| description | Most patients with active vitiligo (82% of 61) have antibodies to antigens of normal human melanocytes that can be detected by specific immunoprecipitation of radioiodinated, detergent-soluble, melanocyte macromolecules. Such antibodies were present in only 12% of patients with melanoma and in none of 35 patients with nonpigmentary skin diseases. The antibodies were directed to a common antigen(s) on melanocytes that was not present on normal fibroblasts or keratinocytes. These observations suggest that vitiligo is an autoimmune disease mediated by antibodies to melanocyte-associated antigen(s). |
| format | Text |
| id | pubmed-2187087 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1983 |
| publisher | The Rockefeller University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-21870872008-04-17 Antibodies to normal human melanocytes in vitiligo J Exp Med Articles Most patients with active vitiligo (82% of 61) have antibodies to antigens of normal human melanocytes that can be detected by specific immunoprecipitation of radioiodinated, detergent-soluble, melanocyte macromolecules. Such antibodies were present in only 12% of patients with melanoma and in none of 35 patients with nonpigmentary skin diseases. The antibodies were directed to a common antigen(s) on melanocytes that was not present on normal fibroblasts or keratinocytes. These observations suggest that vitiligo is an autoimmune disease mediated by antibodies to melanocyte-associated antigen(s). The Rockefeller University Press 1983-07-01 /pmc/articles/PMC2187087/ /pubmed/6345714 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
| spellingShingle | Articles Antibodies to normal human melanocytes in vitiligo |
| title | Antibodies to normal human melanocytes in vitiligo |
| title_full | Antibodies to normal human melanocytes in vitiligo |
| title_fullStr | Antibodies to normal human melanocytes in vitiligo |
| title_full_unstemmed | Antibodies to normal human melanocytes in vitiligo |
| title_short | Antibodies to normal human melanocytes in vitiligo |
| title_sort | antibodies to normal human melanocytes in vitiligo |
| topic | Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187087/ https://www.ncbi.nlm.nih.gov/pubmed/6345714 |