Defective gamma interferon production in leprosy. Reversal with antigen and interleukin 2

Antigen and mitogen-induced gamma interferon (gamma-IFN) production was studied in peripheral blood mononuclear cells from 34 leprosy patients. 17 of 18 lepromatous leprosy and borderline lepromatous patients (LL and BL) failed to release gamma-IFN in response to specific antigen (Mycobacterium lepr...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1983
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187179/
https://www.ncbi.nlm.nih.gov/pubmed/6417263
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description Antigen and mitogen-induced gamma interferon (gamma-IFN) production was studied in peripheral blood mononuclear cells from 34 leprosy patients. 17 of 18 lepromatous leprosy and borderline lepromatous patients (LL and BL) failed to release gamma-IFN in response to specific antigen (Mycobacterium leprae) and displayed reduced responses to mitogen (concanavalin A) stimulation. In contrast, cells from six tuberculoid and borderline tuberculoid patients (TT and BT) produced considerable levels of gamma-IFN under the same experimental conditions. Normal controls failed to respond to M. leprae and most displayed good responses to concanavalin A. Mid-borderline patients (BB) showed intermediate levels of gamma-IFN release. gamma-IFN release by lepromatous patients could be partially restored with purified interleukin 2 and M. leprae antigen but not with interleukin 2 alone.
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spelling pubmed-21871792008-04-17 Defective gamma interferon production in leprosy. Reversal with antigen and interleukin 2 J Exp Med Articles Antigen and mitogen-induced gamma interferon (gamma-IFN) production was studied in peripheral blood mononuclear cells from 34 leprosy patients. 17 of 18 lepromatous leprosy and borderline lepromatous patients (LL and BL) failed to release gamma-IFN in response to specific antigen (Mycobacterium leprae) and displayed reduced responses to mitogen (concanavalin A) stimulation. In contrast, cells from six tuberculoid and borderline tuberculoid patients (TT and BT) produced considerable levels of gamma-IFN under the same experimental conditions. Normal controls failed to respond to M. leprae and most displayed good responses to concanavalin A. Mid-borderline patients (BB) showed intermediate levels of gamma-IFN release. gamma-IFN release by lepromatous patients could be partially restored with purified interleukin 2 and M. leprae antigen but not with interleukin 2 alone. The Rockefeller University Press 1983-12-01 /pmc/articles/PMC2187179/ /pubmed/6417263 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Defective gamma interferon production in leprosy. Reversal with antigen and interleukin 2
title Defective gamma interferon production in leprosy. Reversal with antigen and interleukin 2
title_full Defective gamma interferon production in leprosy. Reversal with antigen and interleukin 2
title_fullStr Defective gamma interferon production in leprosy. Reversal with antigen and interleukin 2
title_full_unstemmed Defective gamma interferon production in leprosy. Reversal with antigen and interleukin 2
title_short Defective gamma interferon production in leprosy. Reversal with antigen and interleukin 2
title_sort defective gamma interferon production in leprosy. reversal with antigen and interleukin 2
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187179/
https://www.ncbi.nlm.nih.gov/pubmed/6417263

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