Cloned LYT-2+ cytolytic T lymphocytes destroy allogeneic tissue in vivo

The long-accepted notion that alloimmune cytolytic T cells (CTL) mediate transplantation immunity has recently been called into question. In order to ascertain directly whether alloimmune CTL can mediate destruction of foreign tissue, we tested the ability of mouse CTL expanded as cloned populations...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1984
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187201/
https://www.ncbi.nlm.nih.gov/pubmed/6198422
_version_ 1782146119731511296
collection PubMed
description The long-accepted notion that alloimmune cytolytic T cells (CTL) mediate transplantation immunity has recently been called into question. In order to ascertain directly whether alloimmune CTL can mediate destruction of foreign tissue, we tested the ability of mouse CTL expanded as cloned populations in vitro to destroy allogeneic skin in vivo. The results of these studies prove unequivocally that cloned Lyt-2+ CTL can perform this task in an immunologically specific, H-2- restricted, and dose-dependent fashion.
format Text
id pubmed-2187201
institution National Center for Biotechnology Information
language English
publishDate 1984
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21872012008-04-17 Cloned LYT-2+ cytolytic T lymphocytes destroy allogeneic tissue in vivo J Exp Med Articles The long-accepted notion that alloimmune cytolytic T cells (CTL) mediate transplantation immunity has recently been called into question. In order to ascertain directly whether alloimmune CTL can mediate destruction of foreign tissue, we tested the ability of mouse CTL expanded as cloned populations in vitro to destroy allogeneic skin in vivo. The results of these studies prove unequivocally that cloned Lyt-2+ CTL can perform this task in an immunologically specific, H-2- restricted, and dose-dependent fashion. The Rockefeller University Press 1984-01-01 /pmc/articles/PMC2187201/ /pubmed/6198422 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Cloned LYT-2+ cytolytic T lymphocytes destroy allogeneic tissue in vivo
title Cloned LYT-2+ cytolytic T lymphocytes destroy allogeneic tissue in vivo
title_full Cloned LYT-2+ cytolytic T lymphocytes destroy allogeneic tissue in vivo
title_fullStr Cloned LYT-2+ cytolytic T lymphocytes destroy allogeneic tissue in vivo
title_full_unstemmed Cloned LYT-2+ cytolytic T lymphocytes destroy allogeneic tissue in vivo
title_short Cloned LYT-2+ cytolytic T lymphocytes destroy allogeneic tissue in vivo
title_sort cloned lyt-2+ cytolytic t lymphocytes destroy allogeneic tissue in vivo
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187201/
https://www.ncbi.nlm.nih.gov/pubmed/6198422

Ejemplares similares