Identification of a specific interleukin 1 inhibitor in the urine of febrile patients

The urine of febrile patients has been found to contain high concentrations of an inhibitor of interleukin 1 (IL-1)-induced thymocyte proliferation. The inhibitor is specific for IL-1 and does not block the effects of interleukin 2 (IL-2) or phytohemagglutin (PHA) on thymocytes, and it is not nonspe...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1984
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187209/
https://www.ncbi.nlm.nih.gov/pubmed/6607312
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description The urine of febrile patients has been found to contain high concentrations of an inhibitor of interleukin 1 (IL-1)-induced thymocyte proliferation. The inhibitor is specific for IL-1 and does not block the effects of interleukin 2 (IL-2) or phytohemagglutin (PHA) on thymocytes, and it is not nonspecifically toxic for these cells. IL- 1 inhibitor can be found in the urine of normal individuals and afebrile patients, but is present in increased concentrations in the urine of patients with fever of diverse etiologies. Preliminary physicochemical characterization indicates that the inhibitor is a 20- 40-kdalton protein.
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spelling pubmed-21872092008-04-17 Identification of a specific interleukin 1 inhibitor in the urine of febrile patients J Exp Med Articles The urine of febrile patients has been found to contain high concentrations of an inhibitor of interleukin 1 (IL-1)-induced thymocyte proliferation. The inhibitor is specific for IL-1 and does not block the effects of interleukin 2 (IL-2) or phytohemagglutin (PHA) on thymocytes, and it is not nonspecifically toxic for these cells. IL- 1 inhibitor can be found in the urine of normal individuals and afebrile patients, but is present in increased concentrations in the urine of patients with fever of diverse etiologies. Preliminary physicochemical characterization indicates that the inhibitor is a 20- 40-kdalton protein. The Rockefeller University Press 1984-01-01 /pmc/articles/PMC2187209/ /pubmed/6607312 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Identification of a specific interleukin 1 inhibitor in the urine of febrile patients
title Identification of a specific interleukin 1 inhibitor in the urine of febrile patients
title_full Identification of a specific interleukin 1 inhibitor in the urine of febrile patients
title_fullStr Identification of a specific interleukin 1 inhibitor in the urine of febrile patients
title_full_unstemmed Identification of a specific interleukin 1 inhibitor in the urine of febrile patients
title_short Identification of a specific interleukin 1 inhibitor in the urine of febrile patients
title_sort identification of a specific interleukin 1 inhibitor in the urine of febrile patients
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187209/
https://www.ncbi.nlm.nih.gov/pubmed/6607312

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