High frequency of lambda gene activation in bone marrow pre-B cells

The frequency of lambda light chain (L) producing cells in immunoglobulin-producing cells that have been generated in vitro from bone marrow pre-B cells was investigated. The frequency of lambda- producing cells obtained in such a culture was three- to eightfold higher than that observed in the cult...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1984
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187214/
https://www.ncbi.nlm.nih.gov/pubmed/6420503
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collection PubMed
description The frequency of lambda light chain (L) producing cells in immunoglobulin-producing cells that have been generated in vitro from bone marrow pre-B cells was investigated. The frequency of lambda- producing cells obtained in such a culture was three- to eightfold higher than that observed in the culture of mature spleen B cells. These results suggest that the activation of lambda gene at pre-B cell stage occurs far more frequently than the frequency presumed from the percentage of lambda-bearing cells in mature B cells.
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spelling pubmed-21872142008-04-17 High frequency of lambda gene activation in bone marrow pre-B cells J Exp Med Articles The frequency of lambda light chain (L) producing cells in immunoglobulin-producing cells that have been generated in vitro from bone marrow pre-B cells was investigated. The frequency of lambda- producing cells obtained in such a culture was three- to eightfold higher than that observed in the culture of mature spleen B cells. These results suggest that the activation of lambda gene at pre-B cell stage occurs far more frequently than the frequency presumed from the percentage of lambda-bearing cells in mature B cells. The Rockefeller University Press 1984-02-01 /pmc/articles/PMC2187214/ /pubmed/6420503 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
High frequency of lambda gene activation in bone marrow pre-B cells
title High frequency of lambda gene activation in bone marrow pre-B cells
title_full High frequency of lambda gene activation in bone marrow pre-B cells
title_fullStr High frequency of lambda gene activation in bone marrow pre-B cells
title_full_unstemmed High frequency of lambda gene activation in bone marrow pre-B cells
title_short High frequency of lambda gene activation in bone marrow pre-B cells
title_sort high frequency of lambda gene activation in bone marrow pre-b cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187214/
https://www.ncbi.nlm.nih.gov/pubmed/6420503

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