The alpha-globin pseudogene on mouse chromosome 17 is closely linked to H-2

DNA sequences homologous to adult alpha-globin genes are dispersed in the mouse. Two functional genes are tightly linked on chromosome 11. Pseudogenes have been assigned to chromosomes 15 and 17 by analysis of interspecies somatic cell hybrids. We have now further characterized the second of these p...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1984
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187240/
https://www.ncbi.nlm.nih.gov/pubmed/6321630
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collection PubMed
description DNA sequences homologous to adult alpha-globin genes are dispersed in the mouse. Two functional genes are tightly linked on chromosome 11. Pseudogenes have been assigned to chromosomes 15 and 17 by analysis of interspecies somatic cell hybrids. We have now further characterized the second of these pseudogenes, Hba-a4. The gene is highly polymorphic, with three forms occurring in a panel of 15 inbred strains and a fourth occurring in an inbred strain derived from M. m. molossinus. Analysis of Hba-a4 alleles in CXB, BXH, and AKXL recombinant inbred strains placed Hba-a4 6.60 +/- 3.14 cM centromeric to H-2. Analysis of congenic mouse strains confirmed the linkage and the gene order. Hba-a4 is the first mammalian dispersed pseudogene to be localized in a linkage map, and should provide a useful marker for the region of chromosome 17 proximal to H-2.
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spelling pubmed-21872402008-04-17 The alpha-globin pseudogene on mouse chromosome 17 is closely linked to H-2 J Exp Med Articles DNA sequences homologous to adult alpha-globin genes are dispersed in the mouse. Two functional genes are tightly linked on chromosome 11. Pseudogenes have been assigned to chromosomes 15 and 17 by analysis of interspecies somatic cell hybrids. We have now further characterized the second of these pseudogenes, Hba-a4. The gene is highly polymorphic, with three forms occurring in a panel of 15 inbred strains and a fourth occurring in an inbred strain derived from M. m. molossinus. Analysis of Hba-a4 alleles in CXB, BXH, and AKXL recombinant inbred strains placed Hba-a4 6.60 +/- 3.14 cM centromeric to H-2. Analysis of congenic mouse strains confirmed the linkage and the gene order. Hba-a4 is the first mammalian dispersed pseudogene to be localized in a linkage map, and should provide a useful marker for the region of chromosome 17 proximal to H-2. The Rockefeller University Press 1984-03-01 /pmc/articles/PMC2187240/ /pubmed/6321630 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
The alpha-globin pseudogene on mouse chromosome 17 is closely linked to H-2
title The alpha-globin pseudogene on mouse chromosome 17 is closely linked to H-2
title_full The alpha-globin pseudogene on mouse chromosome 17 is closely linked to H-2
title_fullStr The alpha-globin pseudogene on mouse chromosome 17 is closely linked to H-2
title_full_unstemmed The alpha-globin pseudogene on mouse chromosome 17 is closely linked to H-2
title_short The alpha-globin pseudogene on mouse chromosome 17 is closely linked to H-2
title_sort alpha-globin pseudogene on mouse chromosome 17 is closely linked to h-2
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187240/
https://www.ncbi.nlm.nih.gov/pubmed/6321630

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