An idiotype-specific helper population that bears immunoglobulin, Ia, and Lyt-1 determinants

A helper cell population with phenotypic characteristics of both B and T cells is described. This helper population, called BH, is present in normal unprimed C57BL/6 mice and preferentially helps the expression of NPb idiotype-bearing plaque-forming B cells in the absence of T helper cells. Its surf...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1984
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187269/
https://www.ncbi.nlm.nih.gov/pubmed/6200563
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description A helper cell population with phenotypic characteristics of both B and T cells is described. This helper population, called BH, is present in normal unprimed C57BL/6 mice and preferentially helps the expression of NPb idiotype-bearing plaque-forming B cells in the absence of T helper cells. Its surface phenotype is Lyt-1.2+, Ig+, Lyb-3+, Thy-1.2-, Lyt- 2.2-. The helper activity of the BH population is IgH restricted and BH cells selectively bind NPb idiotypic determinants. Collectively the data demonstrate that this unique subpopulation can regulate the response of antibody-secreting B cells through specific recognition of idiotypic determinants.
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spelling pubmed-21872692008-04-17 An idiotype-specific helper population that bears immunoglobulin, Ia, and Lyt-1 determinants J Exp Med Articles A helper cell population with phenotypic characteristics of both B and T cells is described. This helper population, called BH, is present in normal unprimed C57BL/6 mice and preferentially helps the expression of NPb idiotype-bearing plaque-forming B cells in the absence of T helper cells. Its surface phenotype is Lyt-1.2+, Ig+, Lyb-3+, Thy-1.2-, Lyt- 2.2-. The helper activity of the BH population is IgH restricted and BH cells selectively bind NPb idiotypic determinants. Collectively the data demonstrate that this unique subpopulation can regulate the response of antibody-secreting B cells through specific recognition of idiotypic determinants. The Rockefeller University Press 1984-04-01 /pmc/articles/PMC2187269/ /pubmed/6200563 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
An idiotype-specific helper population that bears immunoglobulin, Ia, and Lyt-1 determinants
title An idiotype-specific helper population that bears immunoglobulin, Ia, and Lyt-1 determinants
title_full An idiotype-specific helper population that bears immunoglobulin, Ia, and Lyt-1 determinants
title_fullStr An idiotype-specific helper population that bears immunoglobulin, Ia, and Lyt-1 determinants
title_full_unstemmed An idiotype-specific helper population that bears immunoglobulin, Ia, and Lyt-1 determinants
title_short An idiotype-specific helper population that bears immunoglobulin, Ia, and Lyt-1 determinants
title_sort idiotype-specific helper population that bears immunoglobulin, ia, and lyt-1 determinants
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187269/
https://www.ncbi.nlm.nih.gov/pubmed/6200563

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