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T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically

The present report has evaluated the differentiation compartment in which T cells are tolerized to non-major histocompatibility complex (MHC)-encoded minor lymphocyte-stimulating locus (MLS) alloantigens. It was observed that T cell precursors are not tolerized prethymically to MLS alloantigens but...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1983
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187344/
https://www.ncbi.nlm.nih.gov/pubmed/6604122
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collection PubMed
description The present report has evaluated the differentiation compartment in which T cells are tolerized to non-major histocompatibility complex (MHC)-encoded minor lymphocyte-stimulating locus (MLS) alloantigens. It was observed that T cell precursors are not tolerized prethymically to MLS alloantigens but are tolerized intrathymically and postthymically to MLS alloantigens. The failure of prethymic T cells to be tolerized indicates either that T cell precursors are unable to be tolerized to MLS alloantigens or that cells in the prethymic compartment are unable to induce MLS-specific tolerance. In either case, these results demonstrate that the thymus is the initial site in which T cell tolerance to MLS alloantigen is induced. The present results also demonstrate a striking disparity in the reactivity of thymocytes to MHC and MLS alloantigens expressed in the extrathymic host through which their precursors had migrated. In the experimental mice constructed for these studies, intrathymic T cells were tolerant to the MHC alloantigens but were reactive to the MLS alloantigens expressed by the extrathymic host. This observation is consistent with the concept that T cell precursors may be tolerized to MHC alloantigens at an earlier point in their differentiation than they are tolerized to non-MHC- encoded MLS alloantigens.
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spelling pubmed-21873442008-04-17 T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically J Exp Med Articles The present report has evaluated the differentiation compartment in which T cells are tolerized to non-major histocompatibility complex (MHC)-encoded minor lymphocyte-stimulating locus (MLS) alloantigens. It was observed that T cell precursors are not tolerized prethymically to MLS alloantigens but are tolerized intrathymically and postthymically to MLS alloantigens. The failure of prethymic T cells to be tolerized indicates either that T cell precursors are unable to be tolerized to MLS alloantigens or that cells in the prethymic compartment are unable to induce MLS-specific tolerance. In either case, these results demonstrate that the thymus is the initial site in which T cell tolerance to MLS alloantigen is induced. The present results also demonstrate a striking disparity in the reactivity of thymocytes to MHC and MLS alloantigens expressed in the extrathymic host through which their precursors had migrated. In the experimental mice constructed for these studies, intrathymic T cells were tolerant to the MHC alloantigens but were reactive to the MLS alloantigens expressed by the extrathymic host. This observation is consistent with the concept that T cell precursors may be tolerized to MHC alloantigens at an earlier point in their differentiation than they are tolerized to non-MHC- encoded MLS alloantigens. The Rockefeller University Press 1983-08-01 /pmc/articles/PMC2187344/ /pubmed/6604122 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically
title T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically
title_full T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically
title_fullStr T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically
title_full_unstemmed T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically
title_short T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically
title_sort t cell tolerance to non-h-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187344/
https://www.ncbi.nlm.nih.gov/pubmed/6604122