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T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically
The present report has evaluated the differentiation compartment in which T cells are tolerized to non-major histocompatibility complex (MHC)-encoded minor lymphocyte-stimulating locus (MLS) alloantigens. It was observed that T cell precursors are not tolerized prethymically to MLS alloantigens but...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1983
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187344/ https://www.ncbi.nlm.nih.gov/pubmed/6604122 |
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collection | PubMed |
description | The present report has evaluated the differentiation compartment in which T cells are tolerized to non-major histocompatibility complex (MHC)-encoded minor lymphocyte-stimulating locus (MLS) alloantigens. It was observed that T cell precursors are not tolerized prethymically to MLS alloantigens but are tolerized intrathymically and postthymically to MLS alloantigens. The failure of prethymic T cells to be tolerized indicates either that T cell precursors are unable to be tolerized to MLS alloantigens or that cells in the prethymic compartment are unable to induce MLS-specific tolerance. In either case, these results demonstrate that the thymus is the initial site in which T cell tolerance to MLS alloantigen is induced. The present results also demonstrate a striking disparity in the reactivity of thymocytes to MHC and MLS alloantigens expressed in the extrathymic host through which their precursors had migrated. In the experimental mice constructed for these studies, intrathymic T cells were tolerant to the MHC alloantigens but were reactive to the MLS alloantigens expressed by the extrathymic host. This observation is consistent with the concept that T cell precursors may be tolerized to MHC alloantigens at an earlier point in their differentiation than they are tolerized to non-MHC- encoded MLS alloantigens. |
format | Text |
id | pubmed-2187344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1983 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21873442008-04-17 T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically J Exp Med Articles The present report has evaluated the differentiation compartment in which T cells are tolerized to non-major histocompatibility complex (MHC)-encoded minor lymphocyte-stimulating locus (MLS) alloantigens. It was observed that T cell precursors are not tolerized prethymically to MLS alloantigens but are tolerized intrathymically and postthymically to MLS alloantigens. The failure of prethymic T cells to be tolerized indicates either that T cell precursors are unable to be tolerized to MLS alloantigens or that cells in the prethymic compartment are unable to induce MLS-specific tolerance. In either case, these results demonstrate that the thymus is the initial site in which T cell tolerance to MLS alloantigen is induced. The present results also demonstrate a striking disparity in the reactivity of thymocytes to MHC and MLS alloantigens expressed in the extrathymic host through which their precursors had migrated. In the experimental mice constructed for these studies, intrathymic T cells were tolerant to the MHC alloantigens but were reactive to the MLS alloantigens expressed by the extrathymic host. This observation is consistent with the concept that T cell precursors may be tolerized to MHC alloantigens at an earlier point in their differentiation than they are tolerized to non-MHC- encoded MLS alloantigens. The Rockefeller University Press 1983-08-01 /pmc/articles/PMC2187344/ /pubmed/6604122 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically |
title | T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically |
title_full | T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically |
title_fullStr | T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically |
title_full_unstemmed | T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically |
title_short | T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically |
title_sort | t cell tolerance to non-h-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187344/ https://www.ncbi.nlm.nih.gov/pubmed/6604122 |