Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing

We examined the ability of a set of cloned chicken ovalbumin (cOVA)- specific, Id-restricted, T cell hybridomas to produce interleukin-2 in response to cOVA presented by the Ia+ B cell lymphoma line, A20-2J. Although viable A20-2J cells presented native, denatured, and fragmented cOVA more or less e...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1983
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187345/
https://www.ncbi.nlm.nih.gov/pubmed/6193218
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collection PubMed
description We examined the ability of a set of cloned chicken ovalbumin (cOVA)- specific, Id-restricted, T cell hybridomas to produce interleukin-2 in response to cOVA presented by the Ia+ B cell lymphoma line, A20-2J. Although viable A20-2J cells presented native, denatured, and fragmented cOVA more or less equally well, A20-2J cells that were glutaraldehyde-fixed could present only enzymatically or chemically fragmented cOVA. These results suggest that antigen fragmentation may be both necessary and sufficient to define accessory cell processing of soluble antigens so that they may be recognized in association with I- region molecules by T cells.
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spelling pubmed-21873452008-04-17 Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing J Exp Med Articles We examined the ability of a set of cloned chicken ovalbumin (cOVA)- specific, Id-restricted, T cell hybridomas to produce interleukin-2 in response to cOVA presented by the Ia+ B cell lymphoma line, A20-2J. Although viable A20-2J cells presented native, denatured, and fragmented cOVA more or less equally well, A20-2J cells that were glutaraldehyde-fixed could present only enzymatically or chemically fragmented cOVA. These results suggest that antigen fragmentation may be both necessary and sufficient to define accessory cell processing of soluble antigens so that they may be recognized in association with I- region molecules by T cells. The Rockefeller University Press 1983-08-01 /pmc/articles/PMC2187345/ /pubmed/6193218 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing
title Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing
title_full Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing
title_fullStr Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing
title_full_unstemmed Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing
title_short Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing
title_sort antigen recognition by h-2-restricted t cells. i. cell-free antigen processing
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187345/
https://www.ncbi.nlm.nih.gov/pubmed/6193218

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