Identification of a variant of gross leukemia virus that induces disease in mice inoculated as adults

Gross murine leukemia virus normally induces leukemia (thymic lymphoma) in mice inoculated as neonates, but not as adults. We have isolated an apparent variant of this virus which induces thymomas when inoculated i.p. into susceptible adult mice. Using H-2 congenic BALB and C57BL mice, susceptibilit...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1983
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187346/
https://www.ncbi.nlm.nih.gov/pubmed/6886626
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description Gross murine leukemia virus normally induces leukemia (thymic lymphoma) in mice inoculated as neonates, but not as adults. We have isolated an apparent variant of this virus which induces thymomas when inoculated i.p. into susceptible adult mice. Using H-2 congenic BALB and C57BL mice, susceptibility to virus-induced thymomagenesis was found to be linked to the H-2 complex. In addition, a radioresistant immune mechanism leading to inhibition of tumor growth was observed in mice with a C57BL but not a BALB background.
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spelling pubmed-21873462008-04-17 Identification of a variant of gross leukemia virus that induces disease in mice inoculated as adults J Exp Med Articles Gross murine leukemia virus normally induces leukemia (thymic lymphoma) in mice inoculated as neonates, but not as adults. We have isolated an apparent variant of this virus which induces thymomas when inoculated i.p. into susceptible adult mice. Using H-2 congenic BALB and C57BL mice, susceptibility to virus-induced thymomagenesis was found to be linked to the H-2 complex. In addition, a radioresistant immune mechanism leading to inhibition of tumor growth was observed in mice with a C57BL but not a BALB background. The Rockefeller University Press 1983-08-01 /pmc/articles/PMC2187346/ /pubmed/6886626 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Identification of a variant of gross leukemia virus that induces disease in mice inoculated as adults
title Identification of a variant of gross leukemia virus that induces disease in mice inoculated as adults
title_full Identification of a variant of gross leukemia virus that induces disease in mice inoculated as adults
title_fullStr Identification of a variant of gross leukemia virus that induces disease in mice inoculated as adults
title_full_unstemmed Identification of a variant of gross leukemia virus that induces disease in mice inoculated as adults
title_short Identification of a variant of gross leukemia virus that induces disease in mice inoculated as adults
title_sort identification of a variant of gross leukemia virus that induces disease in mice inoculated as adults
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187346/
https://www.ncbi.nlm.nih.gov/pubmed/6886626

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