Lysis of inducer T cell clones by activated macrophages and macrophage- like cell lines

We describe a sequence of reciprocal interactions between cloned inducer T cells and antigen-presenting cells (APC) that results in selective depletion of the antigen-reactive inducer cells. We show that corecognition of antigen and I-A by hapten-reactive inducer T cell clones results in (a) release...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1983
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187388/
https://www.ncbi.nlm.nih.gov/pubmed/6194244
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collection PubMed
description We describe a sequence of reciprocal interactions between cloned inducer T cells and antigen-presenting cells (APC) that results in selective depletion of the antigen-reactive inducer cells. We show that corecognition of antigen and I-A by hapten-reactive inducer T cell clones results in (a) release of macrophage-activating factor (MAF) and other lymphokines, (b) expression of lytic activity by a subset of MAF- sensitized APC after triggering, and (3) lysis (mediated by the activated and triggered macrophage) of the inducer T cell clone and other cells in the vicinity. We suggest that this sequence of steps may limit the extent of macrophage-mediated tissue destruction by depleting the specific inducer T cell clones that initiate the response.
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spelling pubmed-21873882008-04-17 Lysis of inducer T cell clones by activated macrophages and macrophage- like cell lines J Exp Med Articles We describe a sequence of reciprocal interactions between cloned inducer T cells and antigen-presenting cells (APC) that results in selective depletion of the antigen-reactive inducer cells. We show that corecognition of antigen and I-A by hapten-reactive inducer T cell clones results in (a) release of macrophage-activating factor (MAF) and other lymphokines, (b) expression of lytic activity by a subset of MAF- sensitized APC after triggering, and (3) lysis (mediated by the activated and triggered macrophage) of the inducer T cell clone and other cells in the vicinity. We suggest that this sequence of steps may limit the extent of macrophage-mediated tissue destruction by depleting the specific inducer T cell clones that initiate the response. The Rockefeller University Press 1983-10-01 /pmc/articles/PMC2187388/ /pubmed/6194244 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Lysis of inducer T cell clones by activated macrophages and macrophage- like cell lines
title Lysis of inducer T cell clones by activated macrophages and macrophage- like cell lines
title_full Lysis of inducer T cell clones by activated macrophages and macrophage- like cell lines
title_fullStr Lysis of inducer T cell clones by activated macrophages and macrophage- like cell lines
title_full_unstemmed Lysis of inducer T cell clones by activated macrophages and macrophage- like cell lines
title_short Lysis of inducer T cell clones by activated macrophages and macrophage- like cell lines
title_sort lysis of inducer t cell clones by activated macrophages and macrophage- like cell lines
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187388/
https://www.ncbi.nlm.nih.gov/pubmed/6194244

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