Preferential induction of polyclonal IgA secretion by murine Peyer's patch dendritic cell-T cell mixtures

Polyclonal IgA secretion is inducible in murine B cells when DC-T from Peyer's patches (PP) provide the inducing stimulus. PP DC-T, which are composed predominantly of dendritic cells and Lyt-1+ T cells, are capable of dramatic augmentation of IgA secretion by PP or spleen B cells with minimal...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1984
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187398/
https://www.ncbi.nlm.nih.gov/pubmed/6332171
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collection PubMed
description Polyclonal IgA secretion is inducible in murine B cells when DC-T from Peyer's patches (PP) provide the inducing stimulus. PP DC-T, which are composed predominantly of dendritic cells and Lyt-1+ T cells, are capable of dramatic augmentation of IgA secretion by PP or spleen B cells with minimal induction of IgM secretion. DC-T from spleen, however, are incapable of augmenting IgA secretion by either PP or spleen B cells. The level of IgA secretion is dependent upon the dose of DC-T providing the inducing stimulus and reaches a plateau with DC- T:B ratios of less than 1:1. This system for preferential induction of IgA responses should permit elucidation of cellular mechanisms involved in regulation of IgA secretion.
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spelling pubmed-21873982008-04-17 Preferential induction of polyclonal IgA secretion by murine Peyer's patch dendritic cell-T cell mixtures J Exp Med Articles Polyclonal IgA secretion is inducible in murine B cells when DC-T from Peyer's patches (PP) provide the inducing stimulus. PP DC-T, which are composed predominantly of dendritic cells and Lyt-1+ T cells, are capable of dramatic augmentation of IgA secretion by PP or spleen B cells with minimal induction of IgM secretion. DC-T from spleen, however, are incapable of augmenting IgA secretion by either PP or spleen B cells. The level of IgA secretion is dependent upon the dose of DC-T providing the inducing stimulus and reaches a plateau with DC- T:B ratios of less than 1:1. This system for preferential induction of IgA responses should permit elucidation of cellular mechanisms involved in regulation of IgA secretion. The Rockefeller University Press 1984-09-01 /pmc/articles/PMC2187398/ /pubmed/6332171 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Preferential induction of polyclonal IgA secretion by murine Peyer's patch dendritic cell-T cell mixtures
title Preferential induction of polyclonal IgA secretion by murine Peyer's patch dendritic cell-T cell mixtures
title_full Preferential induction of polyclonal IgA secretion by murine Peyer's patch dendritic cell-T cell mixtures
title_fullStr Preferential induction of polyclonal IgA secretion by murine Peyer's patch dendritic cell-T cell mixtures
title_full_unstemmed Preferential induction of polyclonal IgA secretion by murine Peyer's patch dendritic cell-T cell mixtures
title_short Preferential induction of polyclonal IgA secretion by murine Peyer's patch dendritic cell-T cell mixtures
title_sort preferential induction of polyclonal iga secretion by murine peyer's patch dendritic cell-t cell mixtures
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187398/
https://www.ncbi.nlm.nih.gov/pubmed/6332171

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