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Analysis of T cell populations that induce and mediate specific resistance to graft-versus-host disease in rats
F1 hybrid (A X B) rats immunized with parental strain (A) T cells, or which recover from graft-versus-host (GVH) reactions caused by parental T cells, develop strong T cell-mediated immune responses against anti- major histocompatibility complex (MHC) receptor structures on donor T cells specific fo...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1984
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187400/ https://www.ncbi.nlm.nih.gov/pubmed/6206185 |
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collection | PubMed |
description | F1 hybrid (A X B) rats immunized with parental strain (A) T cells, or which recover from graft-versus-host (GVH) reactions caused by parental T cells, develop strong T cell-mediated immune responses against anti- major histocompatibility complex (MHC) receptor structures on donor T cells specific for host (MHCb) alloantigens. This immune response provides the basis for a profound and specific resistance to the subsequent induction in these animals of local or systemic GVH disease. Using subset-specific monoclonal antibodies and negative selection rosetting procedures, we attempted to determine which donor T cell subset possesses the immunogenic idiotypic markers, and which host T cell subpopulation mediates GVH resistance. We show here that the immunizing donor cell population belongs to the W3/25+ helper T cell (Th) subset, the same one that causes local GVH reactions, and that both the W3/25+ Th and the OX8+ killer/suppressor (Tk/s) subsets of host T cells are able to transfer GVH resistance to secondary F1 recipients. |
format | Text |
id | pubmed-2187400 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1984 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21874002008-04-17 Analysis of T cell populations that induce and mediate specific resistance to graft-versus-host disease in rats J Exp Med Articles F1 hybrid (A X B) rats immunized with parental strain (A) T cells, or which recover from graft-versus-host (GVH) reactions caused by parental T cells, develop strong T cell-mediated immune responses against anti- major histocompatibility complex (MHC) receptor structures on donor T cells specific for host (MHCb) alloantigens. This immune response provides the basis for a profound and specific resistance to the subsequent induction in these animals of local or systemic GVH disease. Using subset-specific monoclonal antibodies and negative selection rosetting procedures, we attempted to determine which donor T cell subset possesses the immunogenic idiotypic markers, and which host T cell subpopulation mediates GVH resistance. We show here that the immunizing donor cell population belongs to the W3/25+ helper T cell (Th) subset, the same one that causes local GVH reactions, and that both the W3/25+ Th and the OX8+ killer/suppressor (Tk/s) subsets of host T cells are able to transfer GVH resistance to secondary F1 recipients. The Rockefeller University Press 1984-09-01 /pmc/articles/PMC2187400/ /pubmed/6206185 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Analysis of T cell populations that induce and mediate specific resistance to graft-versus-host disease in rats |
title | Analysis of T cell populations that induce and mediate specific resistance to graft-versus-host disease in rats |
title_full | Analysis of T cell populations that induce and mediate specific resistance to graft-versus-host disease in rats |
title_fullStr | Analysis of T cell populations that induce and mediate specific resistance to graft-versus-host disease in rats |
title_full_unstemmed | Analysis of T cell populations that induce and mediate specific resistance to graft-versus-host disease in rats |
title_short | Analysis of T cell populations that induce and mediate specific resistance to graft-versus-host disease in rats |
title_sort | analysis of t cell populations that induce and mediate specific resistance to graft-versus-host disease in rats |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187400/ https://www.ncbi.nlm.nih.gov/pubmed/6206185 |