Expression of H-2Db on the cell surface in the absence of detectable beta 2 microglobulin

In this report we describe a variant of the C57BL/6 T lymphoma EL4 (EL4/Mar) which, in contrast to the parental cell line, expresses neither H-2Kb nor beta2-microglobulin (beta2m) but which does express H- 2Db detectable by serology and by alloreactive cytotoxic T lymphocytes (CTL). This observation...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1984
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187413/
https://www.ncbi.nlm.nih.gov/pubmed/6376684
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description In this report we describe a variant of the C57BL/6 T lymphoma EL4 (EL4/Mar) which, in contrast to the parental cell line, expresses neither H-2Kb nor beta2-microglobulin (beta2m) but which does express H- 2Db detectable by serology and by alloreactive cytotoxic T lymphocytes (CTL). This observation raises the possibility that H-2Db and perhaps other major histocompatibility complex class I molecules are normally not associated with beta2m on the cell surface. In addition, this report is the first to indicated that alloreactive CTL can interact with a beta2m-free class I antigen.
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spelling pubmed-21874132008-04-17 Expression of H-2Db on the cell surface in the absence of detectable beta 2 microglobulin J Exp Med Articles In this report we describe a variant of the C57BL/6 T lymphoma EL4 (EL4/Mar) which, in contrast to the parental cell line, expresses neither H-2Kb nor beta2-microglobulin (beta2m) but which does express H- 2Db detectable by serology and by alloreactive cytotoxic T lymphocytes (CTL). This observation raises the possibility that H-2Db and perhaps other major histocompatibility complex class I molecules are normally not associated with beta2m on the cell surface. In addition, this report is the first to indicated that alloreactive CTL can interact with a beta2m-free class I antigen. The Rockefeller University Press 1984-07-01 /pmc/articles/PMC2187413/ /pubmed/6376684 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Expression of H-2Db on the cell surface in the absence of detectable beta 2 microglobulin
title Expression of H-2Db on the cell surface in the absence of detectable beta 2 microglobulin
title_full Expression of H-2Db on the cell surface in the absence of detectable beta 2 microglobulin
title_fullStr Expression of H-2Db on the cell surface in the absence of detectable beta 2 microglobulin
title_full_unstemmed Expression of H-2Db on the cell surface in the absence of detectable beta 2 microglobulin
title_short Expression of H-2Db on the cell surface in the absence of detectable beta 2 microglobulin
title_sort expression of h-2db on the cell surface in the absence of detectable beta 2 microglobulin
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187413/
https://www.ncbi.nlm.nih.gov/pubmed/6376684

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