Expression of Tac antigen on activated normal human B cells

Two-color fluorescence analysis revealed that Tac antigen, which was previously reported to be restricted to T cells, was expressed on a proportion of normal B cells activated by Staphylococcus aureus Cowan I (SAC). Immunoaffinity-purified interleukin 2 (IL-2) induced the proliferation of SAC-activa...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1984
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187446/
https://www.ncbi.nlm.nih.gov/pubmed/6088664
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collection PubMed
description Two-color fluorescence analysis revealed that Tac antigen, which was previously reported to be restricted to T cells, was expressed on a proportion of normal B cells activated by Staphylococcus aureus Cowan I (SAC). Immunoaffinity-purified interleukin 2 (IL-2) induced the proliferation of SAC-activated B cells, and the proliferation was completely inhibited by anti-Tac antibody, which blocked the membrane binding and action of IL-2. These results suggest that an IL-2 receptor system is directly involved in the B cell immune response.
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spelling pubmed-21874462008-04-17 Expression of Tac antigen on activated normal human B cells J Exp Med Articles Two-color fluorescence analysis revealed that Tac antigen, which was previously reported to be restricted to T cells, was expressed on a proportion of normal B cells activated by Staphylococcus aureus Cowan I (SAC). Immunoaffinity-purified interleukin 2 (IL-2) induced the proliferation of SAC-activated B cells, and the proliferation was completely inhibited by anti-Tac antibody, which blocked the membrane binding and action of IL-2. These results suggest that an IL-2 receptor system is directly involved in the B cell immune response. The Rockefeller University Press 1984-08-01 /pmc/articles/PMC2187446/ /pubmed/6088664 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Expression of Tac antigen on activated normal human B cells
title Expression of Tac antigen on activated normal human B cells
title_full Expression of Tac antigen on activated normal human B cells
title_fullStr Expression of Tac antigen on activated normal human B cells
title_full_unstemmed Expression of Tac antigen on activated normal human B cells
title_short Expression of Tac antigen on activated normal human B cells
title_sort expression of tac antigen on activated normal human b cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187446/
https://www.ncbi.nlm.nih.gov/pubmed/6088664

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