Nonspecific recruitment of cytotoxic effector cells in the intestinal mucosa of antigen-primed mice

We have examined cytotoxic responses of lymphocytes derived from the gut epithelium of mice primed systemically and enterically with alloantigens. Both gut intraepithelial (IEL) and splenic lymphocytes from alloantigen-primed mice were found to contain antigen-specific cytotoxic T cell activity. How...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1984
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187520/
https://www.ncbi.nlm.nih.gov/pubmed/6334717
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collection PubMed
description We have examined cytotoxic responses of lymphocytes derived from the gut epithelium of mice primed systemically and enterically with alloantigens. Both gut intraepithelial (IEL) and splenic lymphocytes from alloantigen-primed mice were found to contain antigen-specific cytotoxic T cell activity. However, after priming, gut IEL also developed high levels of natural killer and spontaneous cytotoxic cell activities. We suggest that this nonspecific activation of additional cytotoxic effector populations during an antigen-specific response is an important host immune defense within the intestinal mucosa.
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spelling pubmed-21875202008-04-17 Nonspecific recruitment of cytotoxic effector cells in the intestinal mucosa of antigen-primed mice J Exp Med Articles We have examined cytotoxic responses of lymphocytes derived from the gut epithelium of mice primed systemically and enterically with alloantigens. Both gut intraepithelial (IEL) and splenic lymphocytes from alloantigen-primed mice were found to contain antigen-specific cytotoxic T cell activity. However, after priming, gut IEL also developed high levels of natural killer and spontaneous cytotoxic cell activities. We suggest that this nonspecific activation of additional cytotoxic effector populations during an antigen-specific response is an important host immune defense within the intestinal mucosa. The Rockefeller University Press 1984-12-01 /pmc/articles/PMC2187520/ /pubmed/6334717 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Nonspecific recruitment of cytotoxic effector cells in the intestinal mucosa of antigen-primed mice
title Nonspecific recruitment of cytotoxic effector cells in the intestinal mucosa of antigen-primed mice
title_full Nonspecific recruitment of cytotoxic effector cells in the intestinal mucosa of antigen-primed mice
title_fullStr Nonspecific recruitment of cytotoxic effector cells in the intestinal mucosa of antigen-primed mice
title_full_unstemmed Nonspecific recruitment of cytotoxic effector cells in the intestinal mucosa of antigen-primed mice
title_short Nonspecific recruitment of cytotoxic effector cells in the intestinal mucosa of antigen-primed mice
title_sort nonspecific recruitment of cytotoxic effector cells in the intestinal mucosa of antigen-primed mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187520/
https://www.ncbi.nlm.nih.gov/pubmed/6334717

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