T cell receptors for responses to Mls determinants and allo-H-2 determinants appear to be encoded on different chromosomes

Previous studies have shown that T cell clones specific for strong Mlsa,d determinants concomitantly display apparently random reactivity to allo-H-2 determinants. One explanation for this finding is that T cell recognition of Mlsa,d and allo-H-2 determinants is controlled by separate sets of recept...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187557/
https://www.ncbi.nlm.nih.gov/pubmed/2578545
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collection PubMed
description Previous studies have shown that T cell clones specific for strong Mlsa,d determinants concomitantly display apparently random reactivity to allo-H-2 determinants. One explanation for this finding is that T cell recognition of Mlsa,d and allo-H-2 determinants is controlled by separate sets of receptors. If these receptors were chromosomally unlinked, karyotypically unstable T cell hybrids with dual reactivity for Mlsa,d and particular allo-H-2 determinants would be expected, occasionally, to lose reactivity for one set of determinants, but not the other. The results presented here provide direct support for this prediction.
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spelling pubmed-21875572008-04-17 T cell receptors for responses to Mls determinants and allo-H-2 determinants appear to be encoded on different chromosomes J Exp Med Articles Previous studies have shown that T cell clones specific for strong Mlsa,d determinants concomitantly display apparently random reactivity to allo-H-2 determinants. One explanation for this finding is that T cell recognition of Mlsa,d and allo-H-2 determinants is controlled by separate sets of receptors. If these receptors were chromosomally unlinked, karyotypically unstable T cell hybrids with dual reactivity for Mlsa,d and particular allo-H-2 determinants would be expected, occasionally, to lose reactivity for one set of determinants, but not the other. The results presented here provide direct support for this prediction. The Rockefeller University Press 1985-01-01 /pmc/articles/PMC2187557/ /pubmed/2578545 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
T cell receptors for responses to Mls determinants and allo-H-2 determinants appear to be encoded on different chromosomes
title T cell receptors for responses to Mls determinants and allo-H-2 determinants appear to be encoded on different chromosomes
title_full T cell receptors for responses to Mls determinants and allo-H-2 determinants appear to be encoded on different chromosomes
title_fullStr T cell receptors for responses to Mls determinants and allo-H-2 determinants appear to be encoded on different chromosomes
title_full_unstemmed T cell receptors for responses to Mls determinants and allo-H-2 determinants appear to be encoded on different chromosomes
title_short T cell receptors for responses to Mls determinants and allo-H-2 determinants appear to be encoded on different chromosomes
title_sort t cell receptors for responses to mls determinants and allo-h-2 determinants appear to be encoded on different chromosomes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187557/
https://www.ncbi.nlm.nih.gov/pubmed/2578545

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