Differential expression of H-2Dd and H-2Ld histocompatibility antigens

To determine why the H-2Dd antigen is expressed on the surface of transfected cells at a rate several-fold higher than an analogously transfected H-2Ld molecule, we analyzed both previously described and new H-2 hybrid genes. These genes were constructed by exchanging domains between H-2 genes. Quan...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187564/
https://www.ncbi.nlm.nih.gov/pubmed/3919140
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collection PubMed
description To determine why the H-2Dd antigen is expressed on the surface of transfected cells at a rate several-fold higher than an analogously transfected H-2Ld molecule, we analyzed both previously described and new H-2 hybrid genes. These genes were constructed by exchanging domains between H-2 genes. Quantitative radioimmunoassay indicates that the region of the H-2Dd molecule responsible for its enhanced expression resides in the polymorphic N domain, the first domain of the mature class I molecule.
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spelling pubmed-21875642008-04-17 Differential expression of H-2Dd and H-2Ld histocompatibility antigens J Exp Med Articles To determine why the H-2Dd antigen is expressed on the surface of transfected cells at a rate several-fold higher than an analogously transfected H-2Ld molecule, we analyzed both previously described and new H-2 hybrid genes. These genes were constructed by exchanging domains between H-2 genes. Quantitative radioimmunoassay indicates that the region of the H-2Dd molecule responsible for its enhanced expression resides in the polymorphic N domain, the first domain of the mature class I molecule. The Rockefeller University Press 1985-02-01 /pmc/articles/PMC2187564/ /pubmed/3919140 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Differential expression of H-2Dd and H-2Ld histocompatibility antigens
title Differential expression of H-2Dd and H-2Ld histocompatibility antigens
title_full Differential expression of H-2Dd and H-2Ld histocompatibility antigens
title_fullStr Differential expression of H-2Dd and H-2Ld histocompatibility antigens
title_full_unstemmed Differential expression of H-2Dd and H-2Ld histocompatibility antigens
title_short Differential expression of H-2Dd and H-2Ld histocompatibility antigens
title_sort differential expression of h-2dd and h-2ld histocompatibility antigens
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187564/
https://www.ncbi.nlm.nih.gov/pubmed/3919140

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