Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini

Pilocarpine-induced saliva of the tick, Ixodes dammini, inhibited platelet aggregation triggered by ADP and collagen, as well as platelet- aggregation factor. In addition, we found apyrase activity (which degrades ATP and ADP to AMP and orthophosphate) and an anticoagulant. We showed the presence of...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187567/
https://www.ncbi.nlm.nih.gov/pubmed/2982989
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collection PubMed
description Pilocarpine-induced saliva of the tick, Ixodes dammini, inhibited platelet aggregation triggered by ADP and collagen, as well as platelet- aggregation factor. In addition, we found apyrase activity (which degrades ATP and ADP to AMP and orthophosphate) and an anticoagulant. We showed the presence of prostaglandin E2 (PGE2) by bioassay and radioimmunoassay. This saliva inhibited interleukin 2 production by T cell hybridomas, an activity consistent with that of PGE2. A kininase was demonstrated, and this may counteract the algesia- and edema- promoting properties of PGE2. Together, these salivary components produce antihemostatic, antiinflammatory, and immunosuppressive effects that may facilitate feeding, as well as transmission of tick-borne pathogens.
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spelling pubmed-21875672008-04-17 Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini J Exp Med Articles Pilocarpine-induced saliva of the tick, Ixodes dammini, inhibited platelet aggregation triggered by ADP and collagen, as well as platelet- aggregation factor. In addition, we found apyrase activity (which degrades ATP and ADP to AMP and orthophosphate) and an anticoagulant. We showed the presence of prostaglandin E2 (PGE2) by bioassay and radioimmunoassay. This saliva inhibited interleukin 2 production by T cell hybridomas, an activity consistent with that of PGE2. A kininase was demonstrated, and this may counteract the algesia- and edema- promoting properties of PGE2. Together, these salivary components produce antihemostatic, antiinflammatory, and immunosuppressive effects that may facilitate feeding, as well as transmission of tick-borne pathogens. The Rockefeller University Press 1985-02-01 /pmc/articles/PMC2187567/ /pubmed/2982989 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini
title Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini
title_full Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini
title_fullStr Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini
title_full_unstemmed Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini
title_short Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini
title_sort antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, ixodes dammini
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187567/
https://www.ncbi.nlm.nih.gov/pubmed/2982989

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