Induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators

Either of two immunostimulating factors (lpr, lipopolysaccharide) enhanced the pathogenic autoimmune responses of MRL/n mice, but the serologic and immunopathologic characteristics differed. In contrast, either factor acting alone, caused minimal immunopathology in normal mice, despite autoantibody...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187570/
https://www.ncbi.nlm.nih.gov/pubmed/3871835
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collection PubMed
description Either of two immunostimulating factors (lpr, lipopolysaccharide) enhanced the pathogenic autoimmune responses of MRL/n mice, but the serologic and immunopathologic characteristics differed. In contrast, either factor acting alone, caused minimal immunopathology in normal mice, despite autoantibody induction. Combined immunostimulation, however, caused fatal glomerulonephritis in normal-background C57BL/6 mice. These results show the profound influence of the background genome on the effects of immunostimulating agents, and show that resistance to autoimmune disease in immunologically normal mice is not absolute.
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spelling pubmed-21875702008-04-17 Induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators J Exp Med Articles Either of two immunostimulating factors (lpr, lipopolysaccharide) enhanced the pathogenic autoimmune responses of MRL/n mice, but the serologic and immunopathologic characteristics differed. In contrast, either factor acting alone, caused minimal immunopathology in normal mice, despite autoantibody induction. Combined immunostimulation, however, caused fatal glomerulonephritis in normal-background C57BL/6 mice. These results show the profound influence of the background genome on the effects of immunostimulating agents, and show that resistance to autoimmune disease in immunologically normal mice is not absolute. The Rockefeller University Press 1985-02-01 /pmc/articles/PMC2187570/ /pubmed/3871835 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators
title Induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators
title_full Induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators
title_fullStr Induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators
title_full_unstemmed Induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators
title_short Induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators
title_sort induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187570/
https://www.ncbi.nlm.nih.gov/pubmed/3871835

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