Human genes for three complement components that regulate the activation of C3 are tightly linked

A new cluster of complement component genes, including C4BP, C3bR, and FH, is described. Family segregation data indicate that FH is linked to the genes for C4-bp and C4bR, previously reported to be linked and to maintain linkage disequilibrium. This cluster is not linked to the major histocompatibi...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187593/
https://www.ncbi.nlm.nih.gov/pubmed/3157763
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description A new cluster of complement component genes, including C4BP, C3bR, and FH, is described. Family segregation data indicate that FH is linked to the genes for C4-bp and C4bR, previously reported to be linked and to maintain linkage disequilibrium. This cluster is not linked to the major histocompatibility complex, which contains the genes for the complement components, C4, C2, and factor B, or to the C3 locus. These data further suggest that the organization of genes for functionally related proteins in clusters may be a rule for the complement system.
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spelling pubmed-21875932008-04-17 Human genes for three complement components that regulate the activation of C3 are tightly linked J Exp Med Articles A new cluster of complement component genes, including C4BP, C3bR, and FH, is described. Family segregation data indicate that FH is linked to the genes for C4-bp and C4bR, previously reported to be linked and to maintain linkage disequilibrium. This cluster is not linked to the major histocompatibility complex, which contains the genes for the complement components, C4, C2, and factor B, or to the C3 locus. These data further suggest that the organization of genes for functionally related proteins in clusters may be a rule for the complement system. The Rockefeller University Press 1985-05-01 /pmc/articles/PMC2187593/ /pubmed/3157763 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Human genes for three complement components that regulate the activation of C3 are tightly linked
title Human genes for three complement components that regulate the activation of C3 are tightly linked
title_full Human genes for three complement components that regulate the activation of C3 are tightly linked
title_fullStr Human genes for three complement components that regulate the activation of C3 are tightly linked
title_full_unstemmed Human genes for three complement components that regulate the activation of C3 are tightly linked
title_short Human genes for three complement components that regulate the activation of C3 are tightly linked
title_sort human genes for three complement components that regulate the activation of c3 are tightly linked
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187593/
https://www.ncbi.nlm.nih.gov/pubmed/3157763

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