T cell receptor alpha chain genes are located on chromosome 14 at 14q11- 14q12 in humans

A cDNA clone encoding the alpha chain of the human T cell receptor was used in connection with somatic cell human-rodent hybrids to determine that the genes coding for the alpha chain are located on chromosome 14 in humans. In situ hybridization confirms this result and further localizes these genes...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187598/
https://www.ncbi.nlm.nih.gov/pubmed/3872924
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collection PubMed
description A cDNA clone encoding the alpha chain of the human T cell receptor was used in connection with somatic cell human-rodent hybrids to determine that the genes coding for the alpha chain are located on chromosome 14 in humans. In situ hybridization confirms this result and further localizes these genes to 14q11-14q12 on this chromosome. Since this region of chromosome has been shown to be nonrandomly involved in a number of T cell neoplasias, this assignment raises a number of interesting questions as to the possible involvement of the T cell receptor alpha chain genes in tumorigenesis.
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spelling pubmed-21875982008-04-17 T cell receptor alpha chain genes are located on chromosome 14 at 14q11- 14q12 in humans J Exp Med Articles A cDNA clone encoding the alpha chain of the human T cell receptor was used in connection with somatic cell human-rodent hybrids to determine that the genes coding for the alpha chain are located on chromosome 14 in humans. In situ hybridization confirms this result and further localizes these genes to 14q11-14q12 on this chromosome. Since this region of chromosome has been shown to be nonrandomly involved in a number of T cell neoplasias, this assignment raises a number of interesting questions as to the possible involvement of the T cell receptor alpha chain genes in tumorigenesis. The Rockefeller University Press 1985-05-01 /pmc/articles/PMC2187598/ /pubmed/3872924 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
T cell receptor alpha chain genes are located on chromosome 14 at 14q11- 14q12 in humans
title T cell receptor alpha chain genes are located on chromosome 14 at 14q11- 14q12 in humans
title_full T cell receptor alpha chain genes are located on chromosome 14 at 14q11- 14q12 in humans
title_fullStr T cell receptor alpha chain genes are located on chromosome 14 at 14q11- 14q12 in humans
title_full_unstemmed T cell receptor alpha chain genes are located on chromosome 14 at 14q11- 14q12 in humans
title_short T cell receptor alpha chain genes are located on chromosome 14 at 14q11- 14q12 in humans
title_sort t cell receptor alpha chain genes are located on chromosome 14 at 14q11- 14q12 in humans
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187598/
https://www.ncbi.nlm.nih.gov/pubmed/3872924

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