ras Oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma

ras Oncogene p21 antigen is present in the most superficial cells of the normal bladder urothelium, as demonstrated by immunohistochemical staining. The pattern and intensity of p21 staining of cells in epithelial hyperplasia and low grade bladder carcinoma were similar to that seen in the normal ur...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187613/
https://www.ncbi.nlm.nih.gov/pubmed/3886828
_version_ 1782146215752761344
collection PubMed
description ras Oncogene p21 antigen is present in the most superficial cells of the normal bladder urothelium, as demonstrated by immunohistochemical staining. The pattern and intensity of p21 staining of cells in epithelial hyperplasia and low grade bladder carcinoma were similar to that seen in the normal urothelium. In contrast, epithelial cells in "premalignant" (dysplastic) lesions and high grade carcinomas exhibited an intense staining reaction for p21 antigen. ras p21 may be a useful marker for the malignant potential of both premalignant lesions and carcinomas of the bladder.
format Text
id pubmed-2187613
institution National Center for Biotechnology Information
language English
publishDate 1985
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21876132008-04-17 ras Oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma J Exp Med Articles ras Oncogene p21 antigen is present in the most superficial cells of the normal bladder urothelium, as demonstrated by immunohistochemical staining. The pattern and intensity of p21 staining of cells in epithelial hyperplasia and low grade bladder carcinoma were similar to that seen in the normal urothelium. In contrast, epithelial cells in "premalignant" (dysplastic) lesions and high grade carcinomas exhibited an intense staining reaction for p21 antigen. ras p21 may be a useful marker for the malignant potential of both premalignant lesions and carcinomas of the bladder. The Rockefeller University Press 1985-05-01 /pmc/articles/PMC2187613/ /pubmed/3886828 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
ras Oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma
title ras Oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma
title_full ras Oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma
title_fullStr ras Oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma
title_full_unstemmed ras Oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma
title_short ras Oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma
title_sort ras oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187613/
https://www.ncbi.nlm.nih.gov/pubmed/3886828

Ejemplares similares