Interleukin 2-induced proliferation of leukemic human B cells

The proliferative responses of purified leukemic human B cells from nine B cell chronic lymphocytic leukemias to recombinant interleukin 2 (IL-2), spontaneously, and after preactivation by Staphylococcus aureus Cowan I (SAC) or anti-mu antibodies were studied. Three patterns of response were observe...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187614/
https://www.ncbi.nlm.nih.gov/pubmed/3872922
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collection PubMed
description The proliferative responses of purified leukemic human B cells from nine B cell chronic lymphocytic leukemias to recombinant interleukin 2 (IL-2), spontaneously, and after preactivation by Staphylococcus aureus Cowan I (SAC) or anti-mu antibodies were studied. Three patterns of response were observed: (a) no response (three cases); (b) a moderate spontaneous response enhanced by anti-mu (one case); (c) a high proliferative response after preactivation by anti-mu and/or SAC (five cases). IL-2 could also trigger normal B cells, purified from spleen, to proliferative after preactivation by anti-mu or SAC. These results provide evidence that IL-2 is a lymphokine that acts physiologically on both B and T cells.
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spelling pubmed-21876142008-04-17 Interleukin 2-induced proliferation of leukemic human B cells J Exp Med Articles The proliferative responses of purified leukemic human B cells from nine B cell chronic lymphocytic leukemias to recombinant interleukin 2 (IL-2), spontaneously, and after preactivation by Staphylococcus aureus Cowan I (SAC) or anti-mu antibodies were studied. Three patterns of response were observed: (a) no response (three cases); (b) a moderate spontaneous response enhanced by anti-mu (one case); (c) a high proliferative response after preactivation by anti-mu and/or SAC (five cases). IL-2 could also trigger normal B cells, purified from spleen, to proliferative after preactivation by anti-mu or SAC. These results provide evidence that IL-2 is a lymphokine that acts physiologically on both B and T cells. The Rockefeller University Press 1985-05-01 /pmc/articles/PMC2187614/ /pubmed/3872922 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Interleukin 2-induced proliferation of leukemic human B cells
title Interleukin 2-induced proliferation of leukemic human B cells
title_full Interleukin 2-induced proliferation of leukemic human B cells
title_fullStr Interleukin 2-induced proliferation of leukemic human B cells
title_full_unstemmed Interleukin 2-induced proliferation of leukemic human B cells
title_short Interleukin 2-induced proliferation of leukemic human B cells
title_sort interleukin 2-induced proliferation of leukemic human b cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187614/
https://www.ncbi.nlm.nih.gov/pubmed/3872922

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